Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

The Genomic and Biologic Landscapes of Breast Cancer and Racial Differences.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Basel, Switzerland : MDPI, [2000-
    • الموضوع:
      Breast Neoplasms*/genetics ; Breast Neoplasms*/pathology ; Breast Neoplasms*/epidemiology ; Genomics*/methods; Humans ; Female ; Dysbiosis ; Racial Groups/genetics
    • نبذة مختصرة :
      Breast cancer is a significant health challenge worldwide and is the most frequently diagnosed cancer among women globally. This review provides a comprehensive overview of breast cancer biology, genomics, and microbial dysbiosis, focusing on its various subtypes and racial differences. Breast cancer is primarily classified into carcinomas and sarcomas, with carcinomas constituting most cases. Epidemiology and breast cancer risk factors are important for public health intervention. Staging and grading, based on the TNM and Nottingham grading systems, respectively, are crucial to determining the clinical outcome and treatment decisions. Histopathological subtypes include in situ and invasive carcinomas, such as invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC). The review explores molecular subtypes, including Luminal A, Luminal B, Basal-like (Triple Negative), and HER2-enriched, and delves into breast cancer's histological and molecular progression patterns. Recent research findings related to nuclear and mitochondrial genetic alterations, epigenetic reprogramming, and the role of microbiome dysbiosis in breast cancer and racial differences are also reported. The review also provides an update on breast cancer's current diagnostics and treatment modalities.
    • Grant Information:
      1R21MD019400-01 United States MD NIMHD NIH HHS
    • Contributed Indexing:
      Keywords: breast cancer; microbiome; mtDNA mutations; nuclear DNA mutations; racial differences
    • الموضوع:
      Date Created: 20241217 Date Completed: 20241217 Latest Revision: 20241217
    • الموضوع:
      20241217
    • الرقم المعرف:
      10.3390/ijms252313165
    • الرقم المعرف:
      39684874