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The complete telomere-to-telomere sequence of a mouse genome.

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  • معلومة اضافية
    • المصدر:
      Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
    • بيانات النشر:
      Publication: : Washington, DC : American Association for the Advancement of Science
      Original Publication: New York, N.Y. : [s.n.] 1880-
    • الموضوع:
      Mice*/genetics ; Genome* ; Telomere*/genetics ; Mice, Inbred C57BL*/genetics; Animals ; Haploidy ; Mouse Embryonic Stem Cells ; Repetitive Sequences, Nucleic Acid ; Sequence Analysis, DNA
    • نبذة مختصرة :
      The current reference genome of Mus musculus , GRCm39, has major gaps in both euchromatic and heterochromatic regions associated with repetitive sequences. In this work, we have sequenced and assembled the telomere-to-telomere genome of mouse haploid embryonic stem cells. The results reveal more than 7.7% of previously uncovered sequences of the mouse genome, including ribosomal DNA arrays and pericentromeric and subtelomeric regions, as well as an additional 140 genes predicted to be protein-coding. This study helps to address knowledge gaps in the mouse genome.
    • الموضوع:
      Date Created: 20241205 Date Completed: 20241205 Latest Revision: 20241206
    • الموضوع:
      20241209
    • الرقم المعرف:
      10.1126/science.adq8191
    • الرقم المعرف:
      39636971