Daily versus intermittent iron supplementation among children with iron deficiency anemia: A meta-analysis.

Publisher: Professional Medical Publications Country of Publication: Pakistan NLM ID: 100913117 Publication Model: Print Cited Medium: Print ISSN: 1682-024X (Print) Linking ISSN: 1681715X NLM ISO Abbreviation: Pak J Med Sci Subsets: PubMed not MEDLINE

Original Publication: Karachi, Pakistan : Professional Medical Publications, [2000-

Objective: This meta-analysis aimed to investigate daily versus intermittent iron supplementation among children.
Methods: The author searched the Cochrane Library, PubMed, Medline, and Google Scholar for randomized controlled trials and compared daily versus intermittent iron supplementation. The keywords iron deficiency anemia, iron therapy, daily, twice per week, and once weekly were used. The search was limited to the period January 2012 up to November 2023. The age of participant range from two months to 18 years.
Result: Out of the 735 studies, 540 were eligible after removal of duplication, of them, 28 full texts were screened and only 10 studies were included. Daily iron supplementation was better in improving hemoglobin odd ratio, 0.41, 95 CI, 0.38-0.44, Z=26.53, and p-Value <0.001 than intermittent prescription odd ratio, 0.69, 95 CI, 0.67-0.72, Z=49.98, and P-value < 0.001.
Conclusion: Daily supplementation increased hemoglobin more compared to weekly or twice/week among children with iron deficiency anemia. Further larger studies assessing tolerance and compliance are needed.
Competing Interests: Conflicts of Interest: None.
(Copyright: © Pakistan Journal of Medical Sciences.)

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Keywords: Children; Daily; Intermittent; Iron deficiency anemia; Iron supplementation

Date Created: 20241205 Latest Revision: 20241207

20241209

PMC11613373

10.12669/pjms.40.11.10344

39634908