Association between obesity measurement indexes and symptomatic knee osteoarthritis among the Chinese population: analysis from a nationwide longitudinal study.

Publisher: BioMed Central Country of Publication: England NLM ID: 100968565 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2474 (Electronic) Linking ISSN: 14712474 NLM ISO Abbreviation: BMC Musculoskelet Disord Subsets: MEDLINE

Original Publication: London : BioMed Central, [2000-

Osteoarthritis, Knee*/epidemiology ; Osteoarthritis, Knee*/diagnosis ; Obesity*/epidemiology ; Obesity*/diagnosis ; Obesity*/ethnology; Humans ; Male ; Female ; Longitudinal Studies ; Middle Aged ; Cross-Sectional Studies ; China/epidemiology ; Aged ; Body Mass Index ; Asian People ; Risk Factors ; East Asian People

Background: The current literature lacks robust clinical data and evidence delineating the relationship between obesity measurement indexes and knee osteoarthritis (KOA). Consequently, this investigation seeks to elucidate the potential link between obesity measurement indexes and KOA among Chinese adults in a nationally representative study.
Methods: Firstly, this research performed an observational study in the China Health and Retirement Longitudinal Study (CHARLS). The variables were extracted from interviews and compared between KOA and non-KOA participants. The relationship between obesity measurement indexes and KOA was analyzed by multivariate logistic regression. Restricted cubic spline (RCS) regression tests the nonlinearity of the relationship between obesity measurement indexes and KOA. Subgroup analyses were performed by sex to verify the robustness of the findings.
Results: In this cross-sectional analysis, we found a positive association between obesity measurement indexes and KOA. These results did not change on multiple imputations(BMI: OR = 1.02, 95% CI, 1.01-1.04, P < 0.05; WHtR: OR = 2.85, 95% CI, 1.08-7.51, P < 0.05; BRI: OR = 1.07, 95% CI, 1.01-1.12, P < 0.05; BFP: OR = 1.02 95% CI, 1.00-1.03, P < 0.05). All the effects of obesity measurement indexes with KOA are present in females. None of the stratifying variables significantly affected the association between obesity measurement indexes and KOA. RCS regression test revealed the linear positive correlation between obesity measurement indexes and KOA.
Conclusion: In this cross-sectional study, we found a significant association between obesity measurement indexes and KOA. This relationship is not affected by stratification and confounding factors.
Competing Interests: Declarations. Ethics approval and consent to participate: The real data is publicly available, thus ethics approval was not required. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)

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2020yfyzc27 the Nature Science Foundation of Anhui University of Chinese Medicine; 2308085MH294 the Anhui Provincial Natural Science Foundation; 2022AH050510 the Natural Science Research Project for Anhui Universities; 202104j07020010 the Key Research and Development Projects in Anhui Province

Keywords: CHARLS; Cross-sectional survey; Knee osteoarthritis; Obesity measurement indexes

Date Created: 20241202 Date Completed: 20241203 Latest Revision: 20241205

20241209

PMC11610057

10.1186/s12891-024-08009-5

39623424