Photon-counting in dual-contrast-enhanced computed tomography: a proof-of-concept quantitative biomechanical assessment of articular cartilage.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Cartilage, Articular*/diagnostic imaging ; Cartilage, Articular*/physiology ; Contrast Media*/chemistry ; Tomography, X-Ray Computed*/methods ; Photons* ; Gadolinium*; Animals ; Cattle ; Biomechanical Phenomena ; Organometallic Compounds ; Heterocyclic Compounds ; Proof of Concept Study

This proof-of-concept study explores quantitative imaging of articular cartilage using photon-counting detector computed tomography (PCD-CT) with a dual-contrast agent approach, comparing it to clinical dual-energy CT (DECT). The diffusion of cationic iodinated CA4 + and non-ionic gadolinium-based gadoteridol contrast agents into ex vivo bovine medial tibial plateau cartilage was tracked over 72 h. Continuous maps of the contrast agents' diffusion were created, and correlations with biomechanical indentation parameters (equilibrium and instantaneous moduli, and relaxation time constants) were examined at 28 specific locations. Cartilage at each location was analyzed as full-thickness to ensure a fair comparison, and calibration-based material decomposition was employed for concentration estimation. Both DECT and PCD-CT exhibit strong correlations between CA4 + content and biomechanical parameters, with PCD-CT showing superior significance, especially at later time points. DECT lacks significant correlations with gadoteridol-related parameters, while PCD-CT identifies noteworthy correlations between gadoteridol diffusion and biomechanical parameters. In summary, the experimental PCD-CT setup demonstrates superior accuracy and sensitivity in concentration estimation, suggesting its potential as a more effective tool for quantitatively assessing articular cartilage condition compared to a conventional clinical DECT scanner.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)

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5654199 Competitive State Research Funding of the Kuopio University Catchment Area; 316899 The Research Council of Finland; 307932 The Research Council of Finland; 348410 The Research Council of Finland; 357787 The Research Council of Finland; 5063579 Competitive State Research Funding of the Kuopio University Hospital Catchment Area

Keywords: Articular cartilage; Biomechanical indentation; Contrast-enhanced computed tomography; Dual-energy computed tomography; Osteoarthritis; Photon-counting detector

0 (Contrast Media)
AU0V1LM3JT (Gadolinium)
0199MV609F (gadoteridol)
0 (Organometallic Compounds)
0 (Heterocyclic Compounds)

Date Created: 20241202 Date Completed: 20241202 Latest Revision: 20241205

20241209

PMC11612382

10.1038/s41598-024-78237-1

39622931