Photocatalytic activity and anticancer properties of green synthesized ZnO-MgO-Mn 2 O 3 nanocomposite via Ocimum basilicum L. seed extract.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Nanocomposites*/chemistry ; Zinc Oxide*/chemistry ; Zinc Oxide*/pharmacology ; Plant Extracts*/chemistry ; Plant Extracts*/pharmacology ; Ocimum basilicum*/chemistry ; Manganese Compounds*/chemistry ; Manganese Compounds*/pharmacology ; Magnesium Oxide*/chemistry ; Magnesium Oxide*/pharmacology ; Seeds*/chemistry ; Green Chemistry Technology*/methods; Catalysis ; Humans ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Oxides/chemistry ; Cell Line, Tumor ; Mice

Green synthesis using plant extracts such as Ocimum basilicum L. (OBL) seed has attracted attention due to its sustainable and environmentally friendly nature. In this study, ZnO-MgO-Mn 2 O 3 nanocomposites were synthesized using OBL seed extract at two different calcination temperatures of 500 °C and 600 °C, and evaluated in terms of photocatalytic application and cytotoxicity. Phytochemicals in OBL seeds act as reducing and masking agents in the production route, which leads to the formation of nanomaterials with unique properties. Characterization techniques, including XRD, FE-SEM, and DRS were used to analyze the structural, morphological, and optical features of the nanocomposite. XRD results confirmed increasing crystal size from ~ 32 nm (500 °C) to ~ 84 nm (600 °C). Also, FE-SEM images showed formation of irregularly shaped nanocomposites and the EDX spectra of the samples confirmed the presence of zinc, magnesium, manganese, and oxygen elements. The photocatalytic behavior of the nanocomposite cacined at 500 °C was investigated for different organic pollutants. Removal percentages of 97% for Eriochrome Black T dye (pH = 10 for 90 min), 99% for methylene blue dye (pH = 10 for 60 min), 89% for methyl orange dye (pH = 10 for 105 min), and 86.9% for Rhodamine B dye (pH = 3 for 90 min) were obtained. Moreover, the cytotoxicity of the synthesized nanocomposite at 500 °C was evaluated on the 4T1 cell line to investgate its effect on biological systems, and the IC 50 value was obtained around 323 µg/mL.
Competing Interests: Declarations. Competing interests: The authors have declared no conflict of interest. Ethical approval: For this type of study, ethical approval was not.
(© 2024. The Author(s).)

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Keywords: Ocimum basilicum L. seed; Anticancer; Photocatalytic; Plant-mediated synthesis; ZnO-MgO-Mn2O3 nanocomposite

SOI2LOH54Z (Zinc Oxide)
0 (Plant Extracts)
0 (Manganese Compounds)
3A3U0GI71G (Magnesium Oxide)
0 (Antineoplastic Agents)
64J2OA7MH3 (manganese oxide)
0 (Oxides)

Date Created: 20241130 Date Completed: 20241130 Latest Revision: 20241203

20241204

PMC11608275

10.1038/s41598-024-81692-5

39616283