A panoramic view of cell population dynamics in mammalian aging.

Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-

Aging* ; Single-Cell Analysis* ; Transcriptome*; Animals ; Mice ; Male ; Female ; Cellular Senescence ; Immune System ; Gene Expression Profiling ; Organ Specificity ; Lymphocytes/immunology ; Cell Lineage ; Longevity

To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling >20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes. This comprehensive dataset reveals >3000 different cellular states and >200 aging-associated cell populations. Our panoramic analysis uncovered organ-, lineage-, and sex-specific shifts in cellular dynamics during life-span progression. Moreover, we identify both systematic and organ-specific alterations in immune cell populations associated with aging. We further explored the regulatory roles of the immune system on aging and pinpointed specific age-related cell population expansions that are lymphocyte dependent. Our "cell-omics" strategy enhances comprehension of cellular aging and lays the groundwork for exploring the complex cellular regulatory networks in aging and aging-associated diseases.

Update of: bioRxiv. 2024 Mar 05:2024.03.01.583001. doi: 10.1101/2024.03.01.583001.. (PMID: 38496474)

Gut Microbes. 2014;5(5):652-62. (PMID: 25483334)
Nat Commun. 2024 Apr 9;15(1):3074. (PMID: 38594255)
Semin Immunol. 2008 Feb;20(1):14-25. (PMID: 18261920)
Cell Stem Cell. 2023 Nov 2;30(11):1452-1471.e10. (PMID: 37832549)
Science. 2022 Feb 25;375(6583):859-863. (PMID: 35201883)
Front Aging. 2022 Apr 27;3:848925. (PMID: 35821822)
WIREs Mech Dis. 2022 Jul;14(4):e1549. (PMID: 35142107)
Cell. 2018 Aug 9;174(4):982-998.e20. (PMID: 29909982)
Elife. 2018 Sep 28;7:. (PMID: 30265241)
J Immunol. 2009 Nov 15;183(10):6733-43. (PMID: 19864592)
Nature. 2020 Nov;587(7835):619-625. (PMID: 33208946)
Science. 2024 Apr 12;384(6692):eadk6200. (PMID: 38574174)
Anim Front. 2023 Jun 14;13(3):44-54. (PMID: 37324203)
Nat Protoc. 2023 Jan;18(1):188-207. (PMID: 36261634)
Nature. 2020 Nov;587(7832):98-102. (PMID: 33116305)
Immunity. 2015 Sep 15;43(3):502-14. (PMID: 26341401)
Nat Aging. 2024 Nov;4(11):1619-1634. (PMID: 39143318)
Nat Aging. 2021 Jun;1(6):535-549. (PMID: 37117829)
Nat Med. 2019 Dec;25(12):1843-1850. (PMID: 31806903)
Exp Mol Med. 2015 Apr 17;47:e158. (PMID: 25882190)
Nature. 2023 Jul;619(7970):585-594. (PMID: 37468583)
Nat Med. 2023 Jun;29(6):1563-1577. (PMID: 37291214)
Nucleic Acids Res. 2023 Jan 25;51(2):501-516. (PMID: 35929025)
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7218-23. (PMID: 21482780)
Nat Rev Immunol. 2022 Aug;22(8):484-498. (PMID: 34815556)
Genome Res. 2019 Dec;29(12):2088-2103. (PMID: 31754020)
Nat Aging. 2022 Jul;2(7):601-615. (PMID: 36147777)
Aging (Albany NY). 2021 Jun 22;13(12):15875-15897. (PMID: 34156971)
Cold Spring Harb Perspect Biol. 2011 Feb 01;3(2):. (PMID: 21421919)
Sci Rep. 2020 Feb 27;10(1):3594. (PMID: 32107417)
Cell Immunol. 1996 Aug 1;171(2):186-99. (PMID: 8806787)
Nat Rev Drug Discov. 2015 Feb;14(2):130-46. (PMID: 25633797)
Nat Methods. 2017 Oct;14(10):979-982. (PMID: 28825705)
Science. 2023 Nov 3;382(6670):eadf1046. (PMID: 37917687)
Cell Stem Cell. 2022 Jul 7;29(7):1067-1082.e18. (PMID: 35728595)
Nat Commun. 2019 Feb 27;10(1):963. (PMID: 30814501)
Cell Rep. 2023 Aug 29;42(8):112902. (PMID: 37531250)
Nature. 2024 May;629(8010):193-200. (PMID: 38600383)
Front Immunol. 2018 Jul 18;9:1606. (PMID: 30072987)
Front Immunol. 2022 Jul 22;13:863317. (PMID: 35936008)
Nature. 2020 Jul;583(7817):590-595. (PMID: 32669714)
Cell Rep. 2020 Jun 23;31(12):107795. (PMID: 32579922)
Mol Ther Methods Clin Dev. 2022 Mar 16;25:190-204. (PMID: 35434177)
Eur J Immunol. 2003 Sep;33(9):2630-9. (PMID: 12938239)
Front Immunol. 2021 Jun 28;12:585412. (PMID: 34262554)
Science. 2022 May 13;376(6594):eabl4896. (PMID: 35549404)
Cell. 1992 Mar 6;68(5):869-77. (PMID: 1547488)
Int J Endocrinol. 2015;2015:294278. (PMID: 26491440)
Science. 2019 Jul 19;365(6450):. (PMID: 31320509)
Nat Aging. 2024 Jul;4(7):998-1013. (PMID: 38816550)
Science. 2017 Aug 18;357(6352):661-667. (PMID: 28818938)
Nat Commun. 2020 Dec 11;11(1):6374. (PMID: 33311464)
Cell Rep. 2018 Jan 16;22(3):600-610. (PMID: 29346760)
Nature. 2021 Sep;597(7875):250-255. (PMID: 34497389)
Science. 2015 May 22;348(6237):910-4. (PMID: 25953818)
Cell. 2022 Jan 20;185(2):379-396.e38. (PMID: 35021063)
Science. 2020 Sep 11;369(6509):. (PMID: 32913072)
J Pharmacol Exp Ther. 2004 Nov;311(2):728-35. (PMID: 15282264)
BMC Biol. 2017 Feb 7;15(1):7. (PMID: 28173793)
Cell Metab. 2022 Jul 5;34(7):1064-1078.e6. (PMID: 35709763)
Cell Syst. 2019 Apr 24;8(4):281-291.e9. (PMID: 30954476)
Front Immunol. 2016 Jun 21;7:225. (PMID: 27446069)
Nucleic Acids Res. 2021 Jan 8;49(D1):D825-D830. (PMID: 33119753)
Biogerontology. 2021 Apr;22(2):165-187. (PMID: 33502634)
Nature. 2020 Dec;588(7838):466-472. (PMID: 32971526)
Elife. 2021 Apr 13;10:. (PMID: 33847263)
Bioengineered. 2022 Apr;13(4):10786-10802. (PMID: 35485136)
Cell Metab. 2018 May 01;27(5):1026-1039.e6. (PMID: 29606596)
Sci Rep. 2019 Mar 26;9(1):5233. (PMID: 30914743)
Cell. 2018 Feb 22;172(5):1091-1107.e17. (PMID: 29474909)
Nature. 2019 Feb;566(7745):496-502. (PMID: 30787437)
Curr Res Immunol. 2023 May 31;4:100060. (PMID: 37645659)
Cell. 2020 Mar 5;180(5):984-1001.e22. (PMID: 32109414)
J Immunol. 1984 Apr;132(4):1804-8. (PMID: 6607948)
Front Immunol. 2022 Mar 04;13:850998. (PMID: 35309354)
Lipids Health Dis. 2020 Mar 13;19(1):39. (PMID: 32169116)
Genome Biol. 2019 Nov 25;20(1):249. (PMID: 31767039)
Nat Prod Bioprospect. 2022 May 9;12(1):18. (PMID: 35534591)
Nat Metab. 2024 May;6(5):963-979. (PMID: 38693320)
J Clin Invest. 2017 Apr 3;127(4):1392-1404. (PMID: 28240602)
Nat Metab. 2020 Nov;2(11):1332-1349. (PMID: 33139957)
Commun Biol. 2021 Nov 12;4(1):1280. (PMID: 34773081)
Nature. 2018 Oct;562(7727):367-372. (PMID: 30283141)
Mol Metab. 2018 Sep;15:45-55. (PMID: 29858147)
Nat Genet. 2023 Dec;55(12):2104-2116. (PMID: 38036784)
Science. 2023 Jun 16;380(6650):eadg0934. (PMID: 37319212)
Nature. 2022 Mar;603(7903):926-933. (PMID: 35296864)
Sci Transl Med. 2022 Jun 15;14(649):eabo0686. (PMID: 35704599)
Immunity. 2021 Jan 12;54(1):99-115.e12. (PMID: 33271118)
J Immunol Res. 2016;2016:8426874. (PMID: 27493973)
Front Immunol. 2013 Aug 19;4:241. (PMID: 23966998)
Nat Cell Biol. 2023 Mar;25(3):390-403. (PMID: 36717627)

OT2 OD033760 United States OD NIH HHS; U24 HG002371 United States HG NHGRI NIH HHS; RM1 HG011014 United States HG NHGRI NIH HHS; RF1 MH132662 United States MH NIMH NIH HHS; DP2 HG012522 United States HG NHGRI NIH HHS; R01 AG076932 United States AG NIA NIH HHS

Date Created: 20241128 Date Completed: 20250117 Latest Revision: 20250318

20250318

PMC11910726

10.1126/science.adn3949

39607904