Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Green synthesis of zinc nanoparticles by hydroalcoholic extract of lavender (Lavandula stoechas L.), characterization, and cytotoxic effects on human breast and colon cancer.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
    • نبذة مختصرة :
      Green synthesis is the production of metal nanoparticles (MNPs) with biological agents, including plant extracts; it is environmentally friendly. The study aimed to investigate the cytotoxic effects of zinc nanoparticles (ZnNPs) synthesized by the hydroalcoholic extract of lavender (Lavandula stoechas L.) against MCF7 and HT29 with the approach of identifying the ability of these NPs to produce anticancer drugs. ZnNPs are synthesized using the hydroalcoholic extract of the lavender. Nanoparticles (NPs) are evaluated and characterized by the Tyndall effect, UV-Vis, DLS, FT-IR, Zeta-P, Raman spectroscopy, SEM, AFM, and XRD methods. The cytotoxic effects of produced NPs against MCF7 and HT29 and the healthy cell lines MCF10a and HGF were measured using the MTT Assay. Results show the average size of ZnNPs is 40 and 50 nm at a concentration of 3 mM. The highest level of cytotoxicity of NPs occurred after 48 h and was dependent on dose and time. It was determined that lavender is a suitable option for the green synthesis of ZnNPs and can be used as a stable source for the production of MNPs. Also, the synthesized ZnNPs showed cytotoxic effects against the examined cancer cells, while they did not cause toxicity to healthy cells.
      Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Ethical approval: Human and animal samples were not used in this research.
      (© 2024. The Author(s).)
    • References:
      Curr Mol Med. 2024;24(6):702-711. (PMID: 37202896)
      Heliyon. 2020 May 15;6(5):e03943. (PMID: 32518846)
      Bioengineering (Basel). 2022 Sep 08;9(9):. (PMID: 36134998)
      Molecules. 2022 Oct 19;27(20):. (PMID: 36296652)
      J Nanobiotechnology. 2020 Nov 23;18(1):172. (PMID: 33225973)
      Biotechnol Rep (Amst). 2021 Feb 05;29:e00595. (PMID: 33659193)
      Gastroenterology Res. 2020 Feb;13(1):1-10. (PMID: 32095167)
      J Ethnopharmacol. 2011 Apr 12;134(3):781-8. (PMID: 21291990)
      Heliyon. 2024 Aug 22;10(17):e36608. (PMID: 39263164)
      Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):844-851. (PMID: 30879351)
      Artif Cells Nanomed Biotechnol. 2017 Nov;45(7):1272-1291. (PMID: 27825269)
      Metabolites. 2023 Feb 24;13(3):. (PMID: 36984777)
      Anticancer Res. 2015 Jun;35(6):3147-54. (PMID: 26026074)
      Biol Trace Elem Res. 2021 Jan;199(1):344-370. (PMID: 32377944)
      Sci Rep. 2020 Feb 26;10(1):3445. (PMID: 32103090)
      Biomed Pharmacother. 2023 Aug;164:114984. (PMID: 37321058)
    • Grant Information:
      IR.MUQ.REC.1401.200 Qom University of Medical Science
    • Contributed Indexing:
      Keywords: Lavender; Green synthesis; Hydroalcoholic extract; Zinc nanoparticles
    • الرقم المعرف:
      0 (Plant Extracts)
      J41CSQ7QDS (Zinc)
      0 (Antineoplastic Agents)
    • الموضوع:
      Date Created: 20241128 Date Completed: 20241128 Latest Revision: 20241202
    • الموضوع:
      20241204
    • الرقم المعرف:
      PMC11603038
    • الرقم المعرف:
      10.1038/s41598-024-81295-0
    • الرقم المعرف:
      39604480