A Combined Extract Derived from Black Sticky Rice and Dill Improves Clinical Symptoms and Ischemic Stroke Biomarkers in Transient Ischemic Attack and Ischemic Stroke Patients.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Biomarkers*/blood ; Ischemic Attack, Transient*/drug therapy ; Plant Extracts*/pharmacology ; Oryza*/chemistry ; Ischemic Stroke*/drug therapy ; Ischemic Stroke*/blood; Humans ; Male ; Female ; Middle Aged ; Aged ; Adult ; Aged, 80 and over ; Young Adult ; Adolescent ; Double-Blind Method ; Treatment Outcome

Currently, the adjuvant therapy to optimize the restorative process after stroke is required due to the unsatisfied therapeutic efficacy. A combined extract of black sticky rice and dill showed potential in the preclinical state, so we hypothesized that it could provide clinical benefits. A three-arm, randomized, placebo-controlled study was set up to elucidate this issue. Both males and females (18-80 years old) who had experienced transient ischemic attacks or ischemic strokes within the last 5-10 days with an NIHSS score ≤ 7 and received standard treatment were randomly assigned to receive either a placebo or capsule containing a combined extract of black sticky rice and dill at a dose of 600 or 1200 mg per day. The safety parameters, movement control, and degree of disability were assessed 1, 2, and 6 weeks after the intervention, and serum stroke biomarkers were assessed at the mentioned time points, except at 2 weeks. After week 1, the high-dose (1200 mg/day) treatment group had improved NIHSSS, VCAM1, and MMP-9. Both S100β and VCAM1 also improved at week 6, while the low-dose treatment group (600 mg/day) only exhibited improved VCAM1. Therefore, a high dose of the developed adjuvant supplement improves stroke recovery by improving motor impairment by reducing endothelial dysfunction and inflammation.

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P2050054 The National Science and Technology Development Agency

Keywords: ischemic stroke; stroke biomarkers; the combined extract of black sticky rice and dill

0 (Biomarkers)
0 (Plant Extracts)

Date Created: 20241127 Date Completed: 20241127 Latest Revision: 20241205

20250114

PMC11597798

10.3390/nu16223946

39599732