Activins and Inhibins in Cardiovascular Pathophysiology.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, 2011-

Cardiovascular Diseases*/metabolism ; Cardiovascular Diseases*/physiopathology ; Signal Transduction* ; Activins*/metabolism ; Inhibins*/metabolism; Humans ; Animals ; Cardiovascular System/metabolism ; Cardiovascular System/physiopathology

Activins and inhibins, members of the transforming growth factor β (TGFβ) superfamily, were initially recognized for their opposing effects on the secretion of follicle-stimulating hormone. Subsequent research has demonstrated their broader biological roles across various tissue types. Primarily, activins and inhibins function through the classical TGFβ SMAD signaling pathway, but studies suggest that they also act through other pathways, with their specific signaling being complex and context-dependent. Recent research has identified significant roles for activins and inhibins in the cardiovascular system. Their actions in other systems and their signaling pathways show strong correlations with the development and progression of cardiovascular diseases, indicating potential broader roles in the cardiovascular system. This review summarizes the progress in research on the biological functions and mechanisms of activins and inhibins and their signaling pathways in cardiovascular diseases, offering new insights for the prevention and treatment of cardiovascular diseases.

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No. 82100302 National Natural Science Foundation of China

Keywords: TGFβ; activin; cardiovascular disease; inhibin

104625-48-1 (Activins)
57285-09-3 (Inhibins)

Date Created: 20241127 Date Completed: 20241127 Latest Revision: 20241211

20250114

PMC11592067

10.3390/biom14111462

39595638