Alterations of gray matter asymmetry in internet gaming disorder.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Gray Matter*/diagnostic imaging ; Gray Matter*/pathology ; Internet Addiction Disorder*/pathology ; Internet Addiction Disorder*/diagnostic imaging ; Magnetic Resonance Imaging*/methods ; Video Games*; Humans ; Male ; Young Adult ; Adult ; Female ; Brain/diagnostic imaging ; Brain/pathology ; Support Vector Machine ; Behavior, Addictive/pathology ; Behavior, Addictive/diagnostic imaging

Structural asymmetry is a subtle but pervasive property of the human brain, which has been found altered in various psychiatric and neurocognitive disorders. However, little is known regarding potential alterations of structural asymmetry underlying internet gaming disorder (IGD). Therefore, this study aimed to investigate the structural features of gray matter asymmetry in IGD. High-resolution structural magnetic resonance imaging data were collected from 104 individuals with IGD and 104 recreational game users (RGUs). We applied a whole-brain voxel-based asymmetry (VBA) approach to determine the asymmetrical aberrations of gray matter in relation to IGD. Furthermore, the local abnormalities of structural asymmetry were employed as features to examine the effect of classification using a support vector machine (SVM). The results indicated that individuals with IGD as compared to RGUs showed asymmetrical alterations of gray matter in the medial prefrontal cortex (mPFC), orbitofrontal cortex, precuneus, middle temporal gyrus, superior parietal lobule and inferior temporal gyrus, regions implicated in hedonic motivation, self-reflection, information integration and visuospatial attention processing. Moreover, these atypical asymmetrical features can distinguish IGD subjects from RGUs with high accuracy. These results suggested that disrupted structural asymmetry of motivational reward, visuospatial and default mode circuits might be potential biomarkers for identifying pathological gaming dependence. These findings extended our understanding of structural underpinnings of IGD and provided new insights for developing effective interventions to alleviate compulsive gaming usage.
Competing Interests: Declarations Competing interests The authors declare no competing interests.
(© 2024. The Author(s).)

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32100888 National Natural Science Foundation of China Grants; 32200904 National Natural Science Foundation of China Grants; 2021ky247 Medical and Health Technology Project of Zhejiang Provincial Health Commission; LQ21C090007 Zhejiang Natural Science Foundation; LY20C090005 Zhejiang Natural Science Foundation

Date Created: 20241116 Date Completed: 20241116 Latest Revision: 20241121

20250114

PMC11569135

10.1038/s41598-024-79659-7

39550457