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Comparative analysis of the epidemiological characteristics of adenovirus, rotavirus A, and coinfection in children during 2014-2023 in Guangzhou, China.

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  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101231645 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-422X (Electronic) Linking ISSN: 1743422X NLM ISO Abbreviation: Virol J Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: [London] : BioMed Central, 2004-
    • الموضوع:
    • نبذة مختصرة :
      Background: Infection is the cause of diarrhoea, and rotaviruses and adenoviruses are important pathogens in children.
      Methods: A retrospective study was conducted on 144,067 children with diarrhoea between 2014 and 2023 in China. We used the colloidal gold method to detect intestinal adenovirus and rotavirus A antigens in faeces. The epidemiological characteristics of these viruses and the impact of meteorological factors on them were analysed before and after coronavirus disease 2019 (COVID-19) pandemic.
      Results: During this decade, the positive rate of adenovirus infection was 6.41%, while the positive rate of rotavirus A infection was 11.81%, higher than that of adenovirus infection. The positive rate of adenovirus and rotavirus A coinfection was 1.92%. The positive rates of adenovirus, rotavirus A and coinfection showed a fluctuating trend, and suddenly decreased in 2020. There was an apparent decrease of positive rate of rotavirus A, with a decrease of 57.27%, during 2020-2023. Surprisingly, the positive rate of adenovirus infection exceeded that of rotavirus A infection in 2021 and 2023. During the COVID-19 pandemic, the proportion of female patients and children over two years of age infected with adenovirus or rotavirus A increased, while the proportion of cases in winter decreased. In addition, we found that the positive rate of rotavirus A infection was related to average temperature and sunshine, and the positive rate of adenovirus and rotavirus A coinfection was only related to sunshine. However, these correlations disappeared during the COVID-19 pandemic.
      Conclusions: This study revealed the recent prevalence of adenovirus and rotavirus A infections in children with diarrhoea in south-central China and provided a theoretical basis for the prevention and control of viral diarrhoea.
      Competing Interests: Declarations Ethics approval and consent to participate The project was approved by the Ethics Committee of Guangzhou Women and Children’s Medical Center, and the ethical number is 2021-24B01. The data used in this study was anonymized and there was no known risk to participants. Consent for publication Not applicable. Competing interests The authors declare no competing interests.
      (© 2024. The Author(s).)
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    • Grant Information:
      202201011115 the Science and Technology Program of Guangzhou, China; 202201010886 the Science and Technology Program of Guangzhou, China; 2023A04J1251 the Science and Technology Program of Guangzhou, China; SL2024A03J01290 the Guangzhou Basic Research Program 2024 Joint Funding Project between City, Universities
    • Contributed Indexing:
      Keywords: Adenovirus; Children; Diarrhoea; Meteorological factors; Rotavirus A; South-central China
    • الموضوع:
      Date Created: 20241115 Date Completed: 20241116 Latest Revision: 20241117
    • الموضوع:
      20241118
    • الرقم المعرف:
      PMC11566288
    • الرقم المعرف:
      10.1186/s12985-024-02537-1
    • الرقم المعرف:
      39543719