AIDS mortality in Brazil, 2012-2022: a time series study.

Publisher: BioMed Central Country of Publication: England NLM ID: 101237921 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-6405 (Electronic) Linking ISSN: 17426405 NLM ISO Abbreviation: AIDS Res Ther Subsets: MEDLINE

Original Publication: [London] : BioMed Central, 2004-

Acquired Immunodeficiency Syndrome*/mortality ; Acquired Immunodeficiency Syndrome*/epidemiology; Brazil/epidemiology ; Humans ; Male ; Female ; Mortality/trends ; Adult ; HIV Infections/mortality ; HIV Infections/epidemiology ; Middle Aged

Background: Human immunodeficiency virus (HIV) infection is a health problem in Brazil and worldwide. Without treatment, the infection can progress to Acquired Immunodeficiency Syndrome (AIDS), with a high mortality potential. The objective of this study was to analyze the time trend of AIDS mortality in Brazil, macro-regions, federal units and their respective capitals, from 2012 to 2022.
Methods: This is a time-series study of all AIDS deaths in Brazil from 2012 to 2022. The study included the annual number of deaths and the crude and standardized mortality rates. The Joinpoint regression model was used for the time analysis of the standardized rates. Annual percentage change (APC) and average annual percentage change (AAPC) were calculated. A 95% confidence interval (CI) and a 5% significance level were used.
Results: During the period analyzed, 128,678 AIDS deaths were recorded in Brazil, with a crude mortality rate of 6.3/100,000 and a standardized mortality rate of 5.3/100,000. From 2012 to 2020, three regions showed a declining trend in AIDS mortality: Central-West (AAPC - 2.3%; 95%CI -4.3 to -0.21; p = 0.03), Southeast (AAPC - 5.6%; 95%CI -6.8 to -4.0; p < 0.001), and South (AAPC - 4.4%; 95%CI -5.27 to -3.6; p < 0.001). There was also a downward trend in 10 states and 10 capitals. There was an increase in the number of deaths from 2020 onwards in the North, Northeast and Southeast regions compared to 2019.
Conclusion: There was a downward trend in AIDS mortality from 2012 to 2020 and an upward trend from 2020 to 2022. The regional differences observed could reflect the social disparities that exist in Brazil. In addition, the Covid-19 pandemic has had an impact on the process of dealing with HIV in Brazil.
(© 2024. The Author(s).)

J Infect Dis. 2012 Jul 15;206(2):267-74. (PMID: 22675216)
Cad Saude Publica. 2014 Feb;30(2):259-71. (PMID: 24627055)
PLoS One. 2020 Aug 31;15(8):e0238052. (PMID: 32866163)
Einstein (Sao Paulo). 2023 May 29;21:eAO0156. (PMID: 37255057)
Int J STD AIDS. 2021 Feb;32(2):127-134. (PMID: 33342357)
Stat Med. 2000 Feb 15;19(3):335-51. (PMID: 10649300)
AIDS Res Ther. 2019 Sep 6;16(1):25. (PMID: 31492161)
Am J Public Health. 2005 Jul;95(7):1162-72. (PMID: 15933232)
AIDS Behav. 2020 Apr;24(4):1023-1031. (PMID: 30825036)
Cad Saude Publica. 2013 Aug;29(8):1644-53. (PMID: 24005929)
Pathog Glob Health. 2023 Feb;117(1):14-23. (PMID: 35694771)
Sci Rep. 2023 Dec 27;13(1):23003. (PMID: 38155227)
Lancet HIV. 2020 Sep;7(9):e620-e628. (PMID: 32890497)
Glob Health Med. 2022 Feb 28;4(1):1-8. (PMID: 35291198)
Cien Saude Colet. 2022 Mar;27(3):895-908. (PMID: 35293467)
PLoS One. 2017 Dec 15;12(12):e0189055. (PMID: 29244807)
Front Immunol. 2023 Jan 27;14:1104828. (PMID: 36776887)
PLoS One. 2009 May 28;4(5):e5690. (PMID: 19479055)
AIDS. 2007 Jul;21 Suppl 4:S37-45. (PMID: 17620751)
Rev Bras Epidemiol. 2015 Sep;18 Suppl 1:43-62. (PMID: 26630298)
N Engl J Med. 2015 Aug 27;373(9):808-22. (PMID: 26193126)
Front Reprod Health. 2021 Apr 12;3:660672. (PMID: 36303986)
Lancet Reg Health Am. 2023 Jul 17;24:100554. (PMID: 37521440)
Front Pharmacol. 2023 Mar 31;14:1122018. (PMID: 37063259)
PLoS Pathog. 2007 Nov;3(11):e177. (PMID: 18020705)

Date Created: 20241106 Date Completed: 20241106 Latest Revision: 20241108

20241108

PMC11536946

10.1186/s12981-024-00669-6

39501403