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Qualitative and quantitative analysis of 18F-GP1 positron emission tomography in thrombotic cardiovascular disease.

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  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Thrombosis*/diagnostic imaging ; Thrombosis*/metabolism; Humans ; Male ; Female ; Middle Aged ; Aged ; Positron-Emission Tomography/methods ; Positron Emission Tomography Computed Tomography/methods ; Carotid Arteries/diagnostic imaging ; Brain/diagnostic imaging ; Brain/metabolism ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/metabolism ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/metabolism ; Radiopharmaceuticals ; Computed Tomography Angiography/methods ; Ischemic Stroke/diagnostic imaging ; Ischemic Stroke/metabolism ; Fluorine Radioisotopes
    • نبذة مختصرة :
      18 F-GP1 is a novel highly specific radiotracer that binds to activated platelets and thrombus. We aimed to establish the observer repeatability of coronary, carotid and cerebral 18 F-GP1 uptake in patients presenting with acute myocardial infarction or ischaemic stroke. Forty-three patients presenting with acute myocardial infarction or ischaemic stroke underwent hybrid positron emission tomography (PET) and computed tomography (CT) angiography. Qualitative and quantitative assessment of 18 F-GP1 uptake was performed on coronary arteries, carotid arteries and brain parenchyma. Qualitative uptake of 18 F-GP1 had excellent intraobserver and interobserver agreement, with complete agreement for the presence or absence of visual 18 F-GP1 uptake. For quantitative analysis, there were excellent intraclass correlation coefficients for intraobserver repeatability for coronary artery, carotid artery and brain parenchymal SUV max and TBR max measurements (all ≥ 0.92). Coronary artery and brain parenchymal analyses showed the strongest agreement in SUV max values with mean biases of - 0.04 (limits of agreement - 0.21 to 0.20) and 0.02 (limits of agreement - 0.29 to 0.32) respectively. There was good interclass correlation coefficients for interobserver repeatability for coronary artery, carotid artery and brain parenchymal SUV max and TBR max measurements (all ≥ 0.89). The strongest interobserver agreement was seen with brain parenchymal SUV max (mean SUV max 1.95 ± 0.94) and TBR max (mean TBR max 9.55 ± 6.56) with mean biases of - 0.05 (limits of agreement - 0.37 to 0.27) and 0.04 (limits of agreement - 0.59 to 0.52) respectively. Visual qualitative and quantitative 18 F-GP1 PET-CT image analyses provide robust and repeatable measurements of activated platelets and thrombi within the coronary arteries, carotid arteries and brain parenchyma.
      (© 2024. The Author(s).)
    • References:
      J Nucl Med. 2016 Jan;57(1):54-9. (PMID: 26471691)
      JACC Cardiovasc Imaging. 2022 Jun;15(6):1107-1120. (PMID: 35033495)
      Circ Cardiovasc Imaging. 2017 Mar;10(3):. (PMID: 28292859)
      J Am Coll Cardiol. 2020 Jun 23;75(24):3061-3074. (PMID: 32553260)
      Am J Respir Crit Care Med. 2021 Oct 1;204(7):855-856. (PMID: 34375153)
      J Nucl Med. 2017 Apr;58(4):584-589. (PMID: 27754904)
      Stroke. 2013 Jul;44(7):2064-89. (PMID: 23652265)
      J Nucl Cardiol. 2022 Feb;29(1):126-135. (PMID: 32529531)
      JACC Cardiovasc Imaging. 2023 Jun;16(6):820-832. (PMID: 36526577)
      Arterioscler Thromb Vasc Biol. 2023 Sep;43(9):1729-1736. (PMID: 37439259)
      J Chiropr Med. 2016 Jun;15(2):155-63. (PMID: 27330520)
      J Nucl Med. 2018 Jun 29;:. (PMID: 29959214)
      Circulation. 2012 Oct 16;126(16):2020-35. (PMID: 22923432)
      Radiology. 2010 Nov;257(2):516-22. (PMID: 20829536)
      EJNMMI Res. 2017 Dec;7(1):48. (PMID: 28560582)
    • Grant Information:
      5R01HL135557 United States HL NHLBI NIH HHS; FS/CRTF/20/24087 United Kingdom BHF_ British Heart Foundation; FS/CRTF/20/24086 United Kingdom BHF_ British Heart Foundation; FS/ICRF/20/26002 United Kingdom BHF_ British Heart Foundation; FS/CRTF/21/24129 United Kingdom BHF_ British Heart Foundation; FS/14/78/31020 United Kingdom BHF_ British Heart Foundation; R01 HL135557 United States HL NHLBI NIH HHS; MR/Y009932/1 United Kingdom MRC_ Medical Research Council; R01 HL148787 United States HL NHLBI NIH HHS; MR/Y009770/1 United Kingdom MRC_ Medical Research Council; RE/18/5/34216 United Kingdom BHF_ British Heart Foundation; FS/CRTF/22/24377 United Kingdom BHF_ British Heart Foundation; 1R01HL148787-01A1 United States HL NHLBI NIH HHS
    • الرقم المعرف:
      0 (Radiopharmaceuticals)
      0 (Fluorine Radioisotopes)
    • الموضوع:
      Date Created: 20241105 Date Completed: 20241105 Latest Revision: 20241108
    • الموضوع:
      20241108
    • الرقم المعرف:
      PMC11538255
    • الرقم المعرف:
      10.1038/s41598-024-77151-w
    • الرقم المعرف:
      39500930