FOXO3 as a potential diagnostic biomarker for autophagy in rheumatoid arthritis: A bioinformatics study.

Publisher: Taylor & Francis Country of Publication: England NLM ID: 8900070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-842X (Electronic) Linking ISSN: 08916934 NLM ISO Abbreviation: Autoimmunity Subsets: MEDLINE

Publication: 2015- : Abingdon, Oxford : Taylor & Francis
Original Publication: Chur ; New York : Harwood, c1988-

Arthritis, Rheumatoid*/diagnosis ; Arthritis, Rheumatoid*/genetics ; Arthritis, Rheumatoid*/metabolism ; Arthritis, Rheumatoid*/blood ; Arthritis, Rheumatoid*/immunology ; Forkhead Box Protein O3*/genetics ; Forkhead Box Protein O3*/metabolism ; Autophagy*/genetics ; Computational Biology*/methods ; Biomarkers*; Humans ; Gene Expression Profiling ; Synovial Membrane/metabolism ; Synovial Membrane/immunology ; Synovial Membrane/pathology ; Transcriptome ; Gene Expression Regulation

This study aimed to identify genes associated with autophagy and potential diagnostic biomarkers by comparing the gene expression profiles of synovial tissues in patients with rheumatoid arthritis (RA) and healthy individuals, aiming to offer new insights for clinical treatment strategies. We used publicly available datasets to analyze differentially expressed genes (DEGs) between the synovial tissue of RA patients and healthy individuals. Then, we intersected these DEGs with autophagy-related genes to identify autophagy genes in the synovial tissue of RA patients. We further analyzed the biological processes and functions of these genes. Furthermore, we used machine learning to identify characteristic autophagy genes in RA synovial tissue. Finally, we examined the differential expression of these characteristic genes in the blood of RA patients using an external dataset. Our study identified FOXO3 as a potential biomarker for diagnosing RA. FOXO3 gene expression was downregulated in both the synovial tissue and blood of RA patients, suggesting its involvement in multiple biological processes such as local inflammation, oxidative stress, metabolic processes, and immune responses. Our findings suggest that FOXO3 may be a novel biomarker for the clinical diagnosis of RA and may play a crucial role in the pathogenesis of RA. The study provides new insights into the molecular mechanisms of RA and potential new therapeutic targets.

Keywords: FOXO3; Rheumatoid arthritis; autophagy; bioinformatics; biomarker

0 (Forkhead Box Protein O3)
0 (FOXO3 protein, human)
0 (Biomarkers)

Date Created: 20241105 Date Completed: 20241105 Latest Revision: 20241108

20250114

10.1080/08916934.2024.2423759

39498523