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Single-cell sequencing applications in acute myeloid leukemia.

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  • معلومة اضافية
    • المصدر:
      Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2403 (Electronic) Linking ISSN: 10268022 NLM ISO Abbreviation: Leuk Lymphoma Subsets: MEDLINE
    • بيانات النشر:
      Publication: [Philadelphia, PA] : Taylor & Francis
      Original Publication: Chur ; New York : London, UK : Harwood Academic Publishers ; Distributed by STBS, 1989-
    • الموضوع:
      Leukemia, Myeloid, Acute*/genetics ; Leukemia, Myeloid, Acute*/diagnosis ; Leukemia, Myeloid, Acute*/pathology ; Leukemia, Myeloid, Acute*/therapy ; Single-Cell Analysis*/methods ; Biomarkers, Tumor*/genetics; Humans ; Neoplasm, Residual/genetics ; Neoplasm, Residual/diagnosis ; High-Throughput Nucleotide Sequencing/methods ; Clonal Evolution ; Neoplastic Stem Cells/pathology ; Neoplastic Stem Cells/metabolism ; Computational Biology/methods ; Prognosis
    • نبذة مختصرة :
      Acute myeloid leukemia (AML) is a heterogeneous group of malignancies with poor prognosis. AML result from the proliferation of immature myeloid cells blocked at a variable stage of differentiation. Beyond inter-patient heterogeneity, AMLs are characterized by genetic and phenotypic intra-patient heterogeneity. Despite major advances in deciphering AML biology with bulk sequencing studies, pivotal questions remain unanswered. Analyses at the single-cell level could thus transform our understanding of these neoplasms. We review recent progresses in single-cell sequencing technologies from cell processing to bioinformatic pipelines. We next discuss how single-cell applications have helped understand the genetic and functional intra-leukemic heterogeneity, emphasizing aspects related to leukemic stem cells, clonal evolution and measurable residual disease (MRD) monitoring. We finally delineate how single-cell technologies could be implemented in routine clinical practice to improve patient management.
    • Contributed Indexing:
      Keywords: Single-cell; acute myeloid leukemia; clonal architecture; clonal evolution; leukemic microenvironment; leukemic stem cells
    • الرقم المعرف:
      0 (Biomarkers, Tumor)
    • الموضوع:
      Date Created: 20241104 Date Completed: 20250425 Latest Revision: 20250425
    • الموضوع:
      20250426
    • الرقم المعرف:
      10.1080/10428194.2024.2422833
    • الرقم المعرف:
      39496597