Efficacy and safety of high tibial osteotomy combined with platelet-rich plasma for treating knee osteoarthritis: a systematic review and meta-analysis of the Chinese population.

Publisher: BioMed Central Country of Publication: England NLM ID: 100968565 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2474 (Electronic) Linking ISSN: 14712474 NLM ISO Abbreviation: BMC Musculoskelet Disord Subsets: MEDLINE

Original Publication: London : BioMed Central, [2000-

Osteoarthritis, Knee*/surgery ; Osteoarthritis, Knee*/therapy ; Platelet-Rich Plasma* ; Osteotomy*/methods ; Osteotomy*/adverse effects ; Tibia*/surgery; Humans ; Treatment Outcome ; China ; Range of Motion, Articular ; Combined Modality Therapy ; Knee Joint/surgery ; Knee Joint/physiopathology ; East Asian People

Objective: To systematically review the clinical efficacy and safety of high tibial osteotomy (HTO) combined with platelet-rich plasma (PRP) for treating knee osteoarthritis (KOA) and to provide evidence of the effectiveness of evidence-based medicine for treating this disease.
Methods: Clinical studies on the use of HTO combined with PRP for the treatment of KOA before September 2024 were identified. The literature that met the inclusion criteria was strictly screened out, the literature information was extracted, and the data were input into RevMan5.4 for analysis.
Results: Ten studies (12 controls) with 625 patients were included. Overall, the visual analog scale (VAS) score (mean difference (MD) = -0.53, 95% confidence interval (CI) (-0.76, -0.31), P < 0.00001), range of motion (ROM) (MD = 7.24, 95% CI (2.79, 11.69), P = 0.001), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score (MD = -6.91, 95% CI (-9.47, -4.34), P < 0.00001), cartilage recovery (cartilage thickness: MD = 0.43, 95% CI (0.35, 0.51), P < 0.00001; cartilage regeneration: relative risk (RR) = 1.81, 95% CI (1.40, 2.33), P < 0.00001; and the International Cartilage Repair Society (ICRS) grade: RR = 1.96, 95% CI (1.44, 2.66), P < 0.0001), and the Lysholm score (MD = 6.51, 95% CI (4.97, 8.04), P < 0.00001) after HTO-PRP treatment had certain advantages compared to the control group. After treatment, there was no statistically significant difference in the knee joint mechanical axis angle between the HTO-PRP group and the control group (femoral tibial angle (FTA): MD = -0.29, 95% CI (-1.07, 0.49), P = 0.47; medial proximal tibial angle (MPTA): MD = 0.19, 95% CI (-0.49, 0.88), P = 0.58; posterior tibial slope (PTS): MD = -0.12, 95% CI (-0.49, 0.25), P = 0.53; knee varus angle (KVA): MD = -0.30, 95% CI (-1.77, 1.17), P = 0.69; weight-bearing line (WBL): MD = 1.10, 95% CI (-0.89, 3.09), P = 0.28).
Conclusion: The results showed that in the treatment of KOA, the HTO-PRP group had better efficacy than the control groups did and had certain safety reliability.
(© 2024. The Author(s).)

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2021MS454 Sichuan Provincial Administration of Traditional Chinese Medicine; 22-B07 The special fund for 100 Talents Program of the Affiliated Hospital of Chengdu University of TCM; 030058047 The scientific research promotion plan of "Xinglin Scholars" Discipline Talents of Chengdu University of Traditional Chinese Medicine

Keywords: Cartilage repair; High tibial osteotomy; Knee osteoarthritis; Line-of-force correction; Meta-analysis; Platelet-rich plasma

Date Created: 20241102 Date Completed: 20241102 Latest Revision: 20241105

20241105

PMC11529028

10.1186/s12891-024-08004-w

39487422