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HOXA9 and CD163 potentiate pancreatic ductal adenocarcinoma progression.

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  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101251558 Publication Model: Electronic Cited Medium: Internet ISSN: 1746-1596 (Electronic) Linking ISSN: 17461596 NLM ISO Abbreviation: Diagn Pathol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: [London] : BioMed Central, 2006-
    • الموضوع:
    • نبذة مختصرة :
      Background: The role of HOXA9 requires investigations in pancreatic ductal adenocarcinoma (PDAC) as HOXA9 inhibitors are being developed. HOXA9 might attract CD163 expressed tumor associated macrophages (TAM) and could affect PDAC prognosis. This work aims to study the expression and relevance of HOXA9 and CD163 in PDAC progression.
      Materials and Methods: Selected 98 PDAC and 98 adjacent non tumor tissues as a control group were immunostained with HOXA9 and CD163 antibodies.
      Results: PDAC displayed highly significant higher HOXA9 staining intensity, percent and H score values than control group. HOXA9 staining of PDAC cases showed significant associations with poor prognostic indicators including larger tumor size, higher grade and advanced stage. PDAC showed highly significant differences regarding CD163 macrophage-specific staining intensity, percent and H score values than control group. CD163 showed significant higher expressions with larger tumor size, higher histological grade and advanced stage group. HOXA9 staining in PDAC showed highly significant direct correlations with CD163 positive macrophages. Follow up of PDAC cases revealed that high median H score of HOXA9 and CD163 were significantly associated with worse overall survival. CD163 was an independent prognostic marker of worse survival.
      Conclusions: In conclusion, HOXA9 could potentiate PDAC progression by stimulating CD163 expressed TAM attraction in tumors. HOXA9 and CD163 could participate in PDAC therapy. HOXA9 and CD163 could be predictors of worse prognosis and shorter survival in PDAC.
      (© 2024. The Author(s).)
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    • Contributed Indexing:
      Keywords: CD163; HOXA9; Pancreatic ductal adenocarcinoma
    • الرقم المعرف:
      0 (CD163 antigen)
      0 (Antigens, CD)
      0 (Antigens, Differentiation, Myelomonocytic)
      0 (homeobox protein HOXA9)
      0 (Receptors, Cell Surface)
      0 (Homeodomain Proteins)
      0 (Biomarkers, Tumor)
    • الموضوع:
      Date Created: 20241027 Date Completed: 20241027 Latest Revision: 20241104
    • الموضوع:
      20241104
    • الرقم المعرف:
      PMC11514874
    • الرقم المعرف:
      10.1186/s13000-024-01563-5
    • الرقم المعرف:
      39462379