The Potential Effects of Red Wine and Its Components on Neurocognitive Disorders: A Narrative Review.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Wine*/analysis ; Polyphenols*/pharmacology ; Neurocognitive Disorders*/prevention & control; Humans ; Animals ; Alcohol Drinking ; Cognitive Dysfunction/prevention & control ; Brain/drug effects ; Brain/metabolism

Background: The aging population is associated with a net increase in the incidence and prevalence of chronic-degenerative diseases, particularly neurocognitive disorders. Therefore, the identification of preventative strategies to restrain the burden of such chronic conditions is of key relevance. Red wine and its components have accumulated evidence regarding their positive effects in terms of neurological pathologies associated with neurocognitive symptoms.
Methods: Based on this background, the present narrative review aims to summarize the state-of-the-art evidence on the effects of red wine and its components on neurocognitive disorders in both preclinical and clinical settings.
Results: The main findings highlight a protective effect of wine polyphenols present in red wine on dementia in different preclinical models of cognitive decline. The current translational clinical evidence remains uncertain, especially considering the risk-to-benefit ratio of alcohol consumption on brain health.
Conclusions: Given the overall health risks associated with red wine consumption and consistent with the prevailing guidelines in the literature, there is insufficient evidence to support light-to-moderate red wine consumption as an effective strategy for preventing these diseases. However, the largely preclinical findings on polyphenols derived from red wine remain of significant interest in this context.

Oncotarget. 2016 Apr 5;7(14):17380-92. (PMID: 26980711)
Cells. 2022 May 10;11(10):. (PMID: 35626632)
Neurology. 2006 Oct 24;67(8):1370-6. (PMID: 17060562)
Food Funct. 2023 Jul 17;14(14):6346-6362. (PMID: 37403999)
Neurobiol Aging. 2020 Oct;94:24-33. (PMID: 32512325)
Food Chem. 2022 Oct 1;390:133207. (PMID: 35594768)
Bioorg Med Chem Lett. 2014 Jul 15;24(14):3108-12. (PMID: 24878198)
Arch Neurol. 1985 Nov;42(11):1097-105. (PMID: 2864910)
Am J Clin Nutr. 2004 May;79(5):727-47. (PMID: 15113710)
Biophys Chem. 2024 Feb;305:107142. (PMID: 38088006)
J Alzheimers Dis. 2010;22(2):653-61. (PMID: 20858961)
Eur J Nutr. 2016 Mar;55(2):741-747. (PMID: 25851110)
Nutr Neurosci. 2011 Nov;14(6):249-59. (PMID: 22053756)
Front Neurosci. 2017 Jan 31;10:598. (PMID: 28197064)
J Gerontol A Biol Sci Med Sci. 2015 Oct;70(10):1248-54. (PMID: 25881581)
Ageing Res Rev. 2021 May;67:101271. (PMID: 33571701)
Nutrients. 2021 Nov 04;13(11):. (PMID: 34836193)
Am J Clin Nutr. 2002 Nov;76(5):1106-10. (PMID: 12399286)
Pharmacol Res. 2018 Feb;128:338-344. (PMID: 28844841)
Nutrients. 2010 Dec;2(12):1231-46. (PMID: 22254006)
Database (Oxford). 2010;2010:bap024. (PMID: 20428313)
Int J Mol Sci. 2021 Jun 14;22(12):. (PMID: 34198710)
Biomolecules. 2019 May 06;9(5):. (PMID: 31064104)
Nutrients. 2020 Jan 13;12(1):. (PMID: 31941117)
Nutrients. 2018 Oct 01;10(10):. (PMID: 30275380)
Int J Mol Sci. 2021 Apr 28;22(9):. (PMID: 33924876)
J Biol Chem. 2019 Feb 22;294(8):2714-2731. (PMID: 30563837)
Acta Neurobiol Exp (Wars). 2021;81(4):335-349. (PMID: 35014983)
Ann N Y Acad Sci. 2017 Sep;1403(1):48-58. (PMID: 28868614)
Neurotox Res. 2020 Apr;37(4):1009-1017. (PMID: 31997154)
FASEB J. 2006 Nov;20(13):2313-20. (PMID: 17077308)
J Agric Food Chem. 2007 Feb 7;55(3):992-1002. (PMID: 17263504)
Molecules. 2019 Oct 08;24(19):. (PMID: 31597344)
Neurosci Biobehav Rev. 2009 Mar;33(3):394-413. (PMID: 19026680)
Brain Res. 2016 Nov 15;1651:17-26. (PMID: 27639810)
Int J Mol Sci. 2022 Jul 08;23(14):. (PMID: 35886936)
PLoS One. 2014 Jul 17;9(7):e102837. (PMID: 25033451)
EXCLI J. 2020 May 08;19:596-612. (PMID: 32483406)
Int J Biol Macromol. 2021 May 1;178:381-393. (PMID: 33662414)
Curr Neuropharmacol. 2017;15(4):471-479. (PMID: 27012954)
Glob Heart. 2022 Jul 22;17(1):45. (PMID: 36051324)
Biomolecules. 2020 Sep 09;10(9):. (PMID: 32916935)
Front Neurosci. 2021 Jun 16;15:697319. (PMID: 34220446)
Arch Neurol. 2009 Feb;66(2):216-25. (PMID: 19204158)
Pharmacology. 2003 Jun;68(2):81-8. (PMID: 12711835)
Behav Brain Res. 2023 Aug 24;452:114568. (PMID: 37414223)
Br J Nutr. 2002 Apr;87(4):299-306. (PMID: 12064339)
J Gerontol A Biol Sci Med Sci. 2019 Jun 18;74(7):996-1007. (PMID: 30032176)
Neuroimage. 2018 Jul 1;174:177-190. (PMID: 29548848)
J Clin Med. 2020 May 25;9(5):. (PMID: 32466148)
DNA Cell Biol. 2019 Aug;38(8):874-879. (PMID: 31215797)
Am J Cardiol. 2001 Sep 1;88(5):553-5. (PMID: 11524068)
BMJ. 2021 Mar 29;372:n71. (PMID: 33782057)
Curr Opin Clin Nutr Metab Care. 2010 Jan;13(1):14-8. (PMID: 19834324)
J Stroke Cerebrovasc Dis. 2016 Jan;25(1):122-8. (PMID: 26456198)
J Neurosci. 2007 Feb 28;27(9):2349-56. (PMID: 17329432)
Int J Neurol. 1987-1988;21-22:73-82. (PMID: 2980693)
Geriatr Gerontol Int. 2022 Apr;22(4):278-285. (PMID: 35171516)
J Neurochem. 2015 Oct;135(2):416-30. (PMID: 26228682)
J Gerontol A Biol Sci Med Sci. 2004 Aug;59(8):818-26. (PMID: 15345732)
Alzheimers Dement. 2024 May;20(5):3708-3821. (PMID: 38689398)
J Agric Food Chem. 2008 Aug 27;56(16):6910-3. (PMID: 18616261)
Nutrients. 2017 Jan 03;9(1):. (PMID: 28054939)
Age (Dordr). 2015 Jun;37(3):9777. (PMID: 25895558)
Nutrients. 2022 Aug 12;14(16):. (PMID: 36014814)
Biomed Pharmacother. 2019 Aug;116:108999. (PMID: 31146109)
Toxicol In Vitro. 2014 Jun;28(4):544-51. (PMID: 24412540)
Drugs Aging. 2022 Apr;39(4):285-295. (PMID: 35187615)
Front Nutr. 2016 Aug 12;3:31. (PMID: 27570766)
Gerontology. 2003 Nov-Dec;49(6):380-3. (PMID: 14624067)
Front Pharmacol. 2020 May 14;11:694. (PMID: 32477148)
Molecules. 2020 Oct 30;25(21):. (PMID: 33143082)
Mol Nutr Food Res. 2021 Dec;65(23):e2100606. (PMID: 34661340)
Neuropharmacology. 2022 Nov 15;219:109236. (PMID: 36049535)
Molecules. 2020 Nov 16;25(22):. (PMID: 33207644)
J Alzheimers Dis. 2012;29(4):773-82. (PMID: 22349682)
J Pineal Res. 2011 Mar;50(2):110-23. (PMID: 21073519)
J Alzheimers Dis. 2016;50(4):981-98. (PMID: 26890747)
Nutrients. 2023 Jun 17;15(12):. (PMID: 37375690)
Cureus. 2023 Oct 10;15(10):e46786. (PMID: 37954791)
Pharmacol Biochem Behav. 2011 Sep;99(3):316-23. (PMID: 21624386)
Lancet. 2024 Aug 10;404(10452):572-628. (PMID: 39096926)
Rejuvenation Res. 2012 Jun;15(3):322-33. (PMID: 22524206)
Nutrients. 2021 Apr 23;13(5):. (PMID: 33922475)
Nat Neurosci. 2014 Dec;17(12):1798-803. (PMID: 25344629)
Adv Exp Med Biol. 2016;929:377-387. (PMID: 27771934)
J Nutr Sci. 2018 May 21;7:e19. (PMID: 29854398)
Nutr Rev. 2018 Jun 1;76(6):432-443. (PMID: 29596658)
Antioxid Redox Signal. 2004 Oct;6(5):811-8. (PMID: 15345140)
Food Sci Nutr. 2018 Oct 26;6(8):2473-2490. (PMID: 30510749)
J Pharm Pharmacol. 2013 May;65(5):682-8. (PMID: 23600385)
Food Funct. 2014 Apr;5(4):663-70. (PMID: 24569685)
J Am Geriatr Soc. 2015 May;63(5):938-46. (PMID: 25919574)
Int J Mol Sci. 2019 Jan 16;20(2):. (PMID: 30654461)
J Int Neuropsychol Soc. 2012 Jan;18(1):118-27. (PMID: 22115028)
Aging Clin Exp Res. 2021 May;33(5):1175-1185. (PMID: 32488474)
Food Funct. 2018 Dec 13;9(12):6414-6426. (PMID: 30462117)
Front Aging Neurosci. 2019 Mar 01;11:43. (PMID: 30881301)
Age Ageing. 2008 Sep;37(5):505-12. (PMID: 18487267)
Free Radic Biol Med. 2001 Feb 15;30(4):433-46. (PMID: 11182299)
Ann N Y Acad Sci. 2009 Aug;1171:170-5. (PMID: 19723052)
J Neuroinflammation. 2007 Oct 10;4:25. (PMID: 17927823)
Mol Cell Neurosci. 2018 Apr;88:1-6. (PMID: 29223600)
Molecules. 2019 Jul 04;24(13):. (PMID: 31277395)
Pharmacol Res. 2012 Jun;65(6):609-14. (PMID: 22484523)
Front Aging Neurosci. 2014 Mar 14;6:42. (PMID: 24672477)
Pharmacol Biochem Behav. 2016 Jul-Aug;146-147:21-7. (PMID: 27143440)
Cell Mol Neurobiol. 2015 May;35(4):513-22. (PMID: 25471227)
J Transl Med. 2024 Mar 21;22(1):294. (PMID: 38515140)
Arch Med Res. 2001 Sep-Oct;32(5):367-81. (PMID: 11578751)
Food Chem Toxicol. 2017 Dec;110:286-299. (PMID: 29042289)
J Neurochem. 2012 Feb;120(3):461-72. (PMID: 22118570)
Nutr Neurosci. 2023 Sep;26(9):901-912. (PMID: 35943074)
Crit Rev Food Sci Nutr. 2019;59(4):563-579. (PMID: 28933917)
Curr Alzheimer Res. 2023;20(8):588-602. (PMID: 38047366)
J Nutr Biochem. 2016 Aug;34:52-60. (PMID: 27206221)
Neurobiol Dis. 2018 Jun;114:164-173. (PMID: 29534932)
J Altern Complement Med. 2018 Jul;24(7):725-732. (PMID: 29583015)
Behav Pharmacol. 2017 Apr;28(2 and 3-Spec Issue):207-213. (PMID: 27984208)
Toxicol Appl Pharmacol. 2015 Nov 1;288(3):387-98. (PMID: 26307266)
Neurochem Int. 2022 Oct;159:105385. (PMID: 35843421)
J Neurol Neurosurg Psychiatry. 2004 Sep;75(9):1304-8. (PMID: 15314121)
Brain Res. 2016 Nov 1;1650:1-9. (PMID: 27566063)
Neurochem Res. 2018 Feb;43(2):297-305. (PMID: 29090409)
Neurochem Int. 2015 Oct;89:191-7. (PMID: 26235983)
JAMA Netw Open. 2019 Sep 4;2(9):e1910319. (PMID: 31560382)
J Clin Med. 2020 Mar 19;9(3):. (PMID: 32204500)
Biochemistry. 2013 Mar 19;52(11):1893-902. (PMID: 23442089)
Int J Mol Sci. 2010 Mar 31;11(4):1321-42. (PMID: 20480022)
Front Physiol. 2017 Jun 29;8:446. (PMID: 28706491)
Nutr Rev. 2010 Nov;68(11):656-70. (PMID: 20961296)
Mol Med Rep. 2017 Aug;16(2):2095-2100. (PMID: 28656303)
J Alzheimers Dis. 2020;78(3):1245-1257. (PMID: 33252089)
Neurotox Res. 2018 Oct;34(3):749-756. (PMID: 29532445)
Neurochem Int. 2006 Mar;48(4):263-74. (PMID: 16343693)
Nutrients. 2023 Aug 29;15(17):. (PMID: 37686802)
Biochem Biophys Res Commun. 2013 Jun 14;435(4):597-602. (PMID: 23685142)
J Alzheimers Dis. 2018;64(s1):S229-S254. (PMID: 29865058)
Curr Pharm Biotechnol. 2015;16(3):219-44. (PMID: 25601605)
Eur J Epidemiol. 2000 Apr;16(4):357-63. (PMID: 10959944)
FASEB J. 2013 Feb;27(2):769-81. (PMID: 23097297)
Molecules. 2012 Feb 07;17(2):1571-601. (PMID: 22314380)
Metab Brain Dis. 2019 Feb;34(1):257-266. (PMID: 30460524)
J Nutr Biochem. 2021 Mar;89:108569. (PMID: 33321185)
Free Radic Res. 2003 Nov;37(11):1245-52. (PMID: 14703737)
Cells. 2020 Oct 23;9(11):. (PMID: 33114025)
J Sci Food Agric. 2020 Nov;100(14):5093-5101. (PMID: 31157405)
J Med Food. 2022 Aug;25(8):797-806. (PMID: 35353606)
Am J Epidemiol. 2008 Mar 15;167(6):684-91. (PMID: 18222934)
Ann N Y Acad Sci. 2017 Sep;1403(1):150-163. (PMID: 28945939)
Psychiatry Res. 2012 May 31;202(2):118-25. (PMID: 22695315)
Mol Nutr Food Res. 2013 Dec;57(12):2091-102. (PMID: 23963661)
Br J Nutr. 2014 Feb;111(4):715-23. (PMID: 23967806)
Front Neurol. 2014 May 09;5:69. (PMID: 24847308)
Front Neurosci. 2021 Dec 13;15:763476. (PMID: 34966254)
Cell Mol Neurobiol. 2009 Dec;29(8):1169-80. (PMID: 19466539)
J Biol Chem. 2008 Nov 21;283(47):32176-87. (PMID: 18815129)
Int J Mol Sci. 2021 Dec 13;22(24):. (PMID: 34948195)
Mol Neurobiol. 2019 Apr;56(4):2881-2895. (PMID: 30069829)
Neurobiol Learn Mem. 2016 May;131:131-6. (PMID: 27040098)
Neurobiol Aging. 2012 Jul;33(7):1427-39. (PMID: 21196065)
Front Cell Neurosci. 2018 Mar 21;12:72. (PMID: 29618972)
J Neurochem. 2009 Mar;108(6):1410-22. (PMID: 19183254)
J Sci Food Agric. 2023 Nov 27;:. (PMID: 38012025)
Nutr Neurosci. 2016 May;19(4):176-86. (PMID: 26005194)
Chembiochem. 2011 Jul 25;12(11):1749-58. (PMID: 21671331)
Nutrients. 2018 Jun 29;10(7):. (PMID: 29966314)
Antioxidants (Basel). 2021 Jan 02;10(1):. (PMID: 33401699)
Mol Nutr Food Res. 2024 Jan;68(1):e2300472. (PMID: 37888840)
Neurology. 2003 Apr 8;60(7):1077-81. (PMID: 12682309)
Mol Pharmacol. 2010 Sep;78(3):466-77. (PMID: 20554604)
Mol Nutr Food Res. 2015 Jun;59(6):1025-40. (PMID: 25689033)
J Neurosci. 2014 Jun 4;34(23):7862-70. (PMID: 24899709)
Antioxidants (Basel). 2017 Oct 13;6(4):. (PMID: 29027929)
Sci Rep. 2019 Mar 5;9(1):3546. (PMID: 30837576)
Br J Nutr. 2021 Jul 14;126(1):43-52. (PMID: 33028430)
Front Cell Neurosci. 2013 Dec 26;7:281. (PMID: 24421757)
Exp Ther Med. 2014 Apr;7(4):843-848. (PMID: 24660032)
FEBS J. 2021 Apr;288(7):2347-2359. (PMID: 32981207)
Eur J Epidemiol. 2017 Jan;32(1):31-42. (PMID: 28097521)
Free Radic Biol Med. 2014 Oct;75 Suppl 1:S45. (PMID: 26461383)
Front Nutr. 2022 Aug 02;9:966276. (PMID: 35983489)
Neurotox Res. 2023 Dec;41(6):670-680. (PMID: 37713032)
Diseases. 2018 Jul 22;6(3):. (PMID: 30037152)
J Alzheimers Dis. 2009;16(1):59-72. (PMID: 19158422)
Res Integr Peer Rev. 2019 Mar 26;4:5. (PMID: 30962953)
Alzheimer Dis Assoc Disord. 2002 Oct-Dec;16(4):203-12. (PMID: 12468894)
Nutr Neurosci. 2016;19(1):32-42. (PMID: 26304685)
ACS Chem Neurosci. 2020 Jun 17;11(12):1770-1780. (PMID: 32437602)
Foods. 2021 Oct 27;10(11):. (PMID: 34828876)
Food Chem Toxicol. 2016 Jul;93:32-40. (PMID: 27133915)
Chem Sci. 2023 Aug 22;14(35):9427-9438. (PMID: 37712018)
ACS Chem Neurosci. 2022 Feb 16;13(4):454-463. (PMID: 35114083)
Antioxidants (Basel). 2023 Jul 20;12(7):. (PMID: 37508001)
Int J Food Sci Nutr. 2023 May;74(3):362-372. (PMID: 37101389)
FASEB J. 2018 Oct;32(10):5390-5404. (PMID: 29702026)
Biochim Biophys Acta. 2013 Nov;1830(11):5068-74. (PMID: 23830862)
Molecules. 2021 Jan 30;26(3):. (PMID: 33573150)
Synapse. 2023 Jul;77(4):e22271. (PMID: 37130656)
Phytother Res. 2013 Mar;27(3):344-9. (PMID: 22585561)
Nutrients. 2023 Apr 16;15(8):. (PMID: 37111141)
Neurochem Res. 2016 Sep;41(9):2367-79. (PMID: 27180189)
Nutrients. 2021 Jan 19;13(1):. (PMID: 33477894)
FEBS J. 2022 Jan;289(1):215-230. (PMID: 34268903)
J Neurochem. 2024 Sep;168(9):1895-1908. (PMID: 38163875)
Ageing Res Rev. 2024 Sep;100:102419. (PMID: 39038743)
PLoS One. 2023 May 25;18(5):e0286143. (PMID: 37228106)
J Biol Chem. 2010 Mar 19;285(12):9100-13. (PMID: 20080969)
Mol Nutr Food Res. 2014 Oct;58(10):1931-40. (PMID: 25066301)
J Vet Sci. 2022 Mar;23(2):e26. (PMID: 35187882)
Biochem Biophys Res Commun. 2023 Sep 3;671:116-123. (PMID: 37300941)
Mass Spectrom Rev. 2003 Jul-Aug;22(4):218-50. (PMID: 12884388)
Mol Neurobiol. 2010 Jun;41(2-3):375-83. (PMID: 20306310)
Brain Res Bull. 2003 Nov 15;62(1):29-38. (PMID: 14596889)
Front Behav Neurosci. 2016 Feb 09;10:9. (PMID: 26903826)
Diseases. 2018 Nov 18;6(4):. (PMID: 30453669)
Neurochem Res. 2009 Jun;34(6):1120-8. (PMID: 19030989)
Ann N Y Acad Sci. 2004 Dec;1030:317-29. (PMID: 15659813)
Lancet Oncol. 2021 Aug;22(8):1071-1080. (PMID: 34270924)
Molecules. 2022 May 12;27(10):. (PMID: 35630586)
Food Funct. 2020 Jul 22;11(7):6170-6185. (PMID: 32578648)
Basic Clin Neurosci. 2018 Sep-Oct;9(5):317-324. (PMID: 30719246)
Neurochem Int. 2009 Feb;54(2):111-8. (PMID: 19041676)
Brain. 2024 Mar 1;147(3):923-935. (PMID: 37757857)
Bioorg Med Chem. 2007 Jan 15;15(2):1160-7. (PMID: 17049256)
Molecules. 2017 Feb 14;22(2):. (PMID: 28216605)
Crit Rev Food Sci Nutr. 2005;45(2):85-118. (PMID: 15941014)
J Alzheimers Dis. 2016 Nov 1;55(1):115-135. (PMID: 27662290)
Curr Alzheimer Res. 2016;13(12):1356-1362. (PMID: 27628432)
J Alzheimers Dis. 2018;64(3):835-857. (PMID: 29914019)
Mol Biosyst. 2015 Jul;11(7):2031-41. (PMID: 25973904)
Curr Med Chem. 2019;26(27):5152-5164. (PMID: 28971760)
Neurotoxicology. 2009 Nov;30(6):986-95. (PMID: 19744518)
Nutrients. 2019 Sep 21;11(10):. (PMID: 31546671)
Neurology. 2018 May 29;90(22):e1979-e1988. (PMID: 29703769)
Circulation. 1999 Sep 7;100(10):1050-5. (PMID: 10477529)
Curr Drug Targets. 2006 Apr;7(4):423-42. (PMID: 16611030)
J Agric Food Chem. 2012 Jun 13;60(23):5736-42. (PMID: 22468945)
Front Nutr. 2021 Dec 16;8:780226. (PMID: 34977124)
Br J Nutr. 2010 Mar;103(5):730-4. (PMID: 20028599)
Molecules. 2022 Dec 11;27(24):. (PMID: 36557912)
Postgrad Med J. 2006 Feb;82(964):84-8. (PMID: 16461469)
J Alzheimers Dis. 2014;42(4):1209-20. (PMID: 25024312)
Curr Pharm Biotechnol. 2016;17(11):1008-15. (PMID: 27448396)
Mol Nutr Food Res. 2011 Aug;55(8):1129-41. (PMID: 21688389)
Brain Plast. 2021 Feb 09;6(2):139-153. (PMID: 33782647)
Nutrients. 2023 Jul 30;15(15):. (PMID: 37571327)
Nat Rev Endocrinol. 2018 Oct;14(10):576-590. (PMID: 30046148)
J Nutr Biochem. 2014 Mar;25(3):313-8. (PMID: 24456733)
Front Aging Neurosci. 2023 Nov 16;15:1269952. (PMID: 38046466)
Br J Pharmacol. 2000 Oct;131(4):711-20. (PMID: 11030720)
Behav Brain Res. 2018 Sep 3;349:1-7. (PMID: 29715537)
Mol Med Rep. 2019 May;19(5):3783-3790. (PMID: 30864708)
Neurosci Lett. 2000 Mar 10;281(2-3):123-6. (PMID: 10704758)
Biochim Biophys Acta. 2004 Nov 5;1690(3):193-202. (PMID: 15511626)
Brain Res. 2006 Sep 21;1111(1):41-7. (PMID: 16876771)
Behav Brain Res. 2014 May 1;264:173-80. (PMID: 24512768)
Age (Dordr). 2013 Oct;35(5):1851-65. (PMID: 23129026)
Nutrients. 2016 Apr 14;8(4):222. (PMID: 27089363)
Life Sci. 2003 Apr 11;72(21):2369-79. (PMID: 12639702)
N Engl J Med. 2023 Dec 28;389(26):2486-2494. (PMID: 38157507)
Biomed Res Int. 2017;2017:9202954. (PMID: 28261618)
Int J Mol Sci. 2023 Mar 14;24(6):. (PMID: 36982583)
ACS Chem Neurosci. 2023 Nov 15;14(22):4051-4061. (PMID: 37890131)
Phytomedicine. 2009 Apr;16(4):287-94. (PMID: 19303757)
Sci Rep. 2017 Oct 23;7(1):13753. (PMID: 29062069)
Front Microbiol. 2021 Dec 03;12:790935. (PMID: 34925298)
J Med Food. 2007 Jun;10(2):218-24. (PMID: 17651055)
J AOAC Int. 2020 Jul 1;103(4):915-924. (PMID: 33241345)
Front Psychol. 2023 Mar 29;14:1144231. (PMID: 37063535)
Molecules. 2016 Sep 17;21(9):. (PMID: 27649135)
Am J Epidemiol. 2007 Jun 15;165(12):1364-71. (PMID: 17369607)
Front Nutr. 2022 Jan 26;8:720756. (PMID: 35155509)
Biol Res. 2004;37(2):189-93. (PMID: 15455646)
Neurotox Res. 2009 Jan;15(1):3-14. (PMID: 19384583)
J Biol Chem. 2005 Nov 11;280(45):37377-82. (PMID: 16162502)
Lancet Public Health. 2023 Jan;8(1):e6-e7. (PMID: 36603913)
Antioxidants (Basel). 2021 Apr 26;10(5):. (PMID: 33926060)
Free Radic Biol Med. 2003 Apr 15;34(8):1100-10. (PMID: 12684095)
Mol Nutr Food Res. 2017 Mar;61(3):. (PMID: 27794200)
J Biomol Struct Dyn. 2024 Jan-Feb;42(2):1088-1097. (PMID: 37011009)
Neuromolecular Med. 2016 Sep;18(3):378-95. (PMID: 27455862)
J Nutr Sci. 2017 Jul 12;6:e35. (PMID: 29152239)

Keywords: clinical studies; dementia; neurocognitive disorders; neurodegenerative diseases; polyphenols; preclinical studies; prevention; red wine; resveratrol

0 (Polyphenols)

Date Created: 20241026 Date Completed: 20241026 Latest Revision: 20241028

20241028

PMC11510231

10.3390/nu16203431

39458427