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BIN2 inhibition suppress ovarian cancer progression meanwhile protect ovarian function through downregulating HDAC1 and RPS6 phosphorylation respectively.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Wiley Country of Publication: United States NLM ID: 101597971 Publication Model: Print Cited Medium: Internet ISSN: 2001-1326 (Electronic) Linking ISSN: 20011326 NLM ISO Abbreviation: Clin Transl Med Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2020- : [Hoboken, NJ] : Wiley
      Original Publication: Heidelberg : Springer-Verlag
    • الموضوع:
      Histone Deacetylase 1*/metabolism ; Ovarian Neoplasms*/metabolism ; Ovarian Neoplasms*/genetics; Animals ; Female ; Humans ; Mice ; Adaptor Proteins, Signal Transducing/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Disease Progression ; Down-Regulation/drug effects ; Ovary/metabolism ; Phosphorylation/drug effects ; Ribosomal Proteins/metabolism ; Tumor Suppressor Proteins/metabolism ; Tumor Suppressor Proteins/genetics
    • References:
      Cell Death Dis. 2021 May 11;12(5):469. (PMID: 33976119)
      Nature. 2016 May 25;534(7605):55-62. (PMID: 27251275)
      Nat Commun. 2021 Sep 13;12(1):5397. (PMID: 34518534)
      Clin Cancer Res. 2001 Apr;7(4):962-70. (PMID: 11309347)
      Nat Genet. 2020 Feb;52(2):187-197. (PMID: 31913353)
      J Proteomics. 2014 Jan 16;96:253-62. (PMID: 24275569)
      J Proteomics. 2013 Oct 08;91:286-96. (PMID: 23911959)
      Clin Cancer Res. 2015 Jan 15;21(2):428-38. (PMID: 25593344)
      Nat Aging. 2021 Nov;1(11):1010-1023. (PMID: 37118338)
    • Grant Information:
      SBGJ202001002 Major Projects in Provincial and National Union Construction of Henan Medical Science Research Plan; 32070840 National Natural Science Foundation of China; 2021YFA1100300 National Key R&D Program of China; 2021YFC2700602 National Key Research & Development Project; FXK201712 Jiangsu Provincial Key Department of Maternal and Child Health Fund
    • الرقم المعرف:
      0 (Adaptor Proteins, Signal Transducing)
      EC 3.5.1.98 (HDAC1 protein, human)
      EC 3.5.1.98 (Histone Deacetylase 1)
      0 (Ribosomal Proteins)
      0 (Tumor Suppressor Proteins)
    • الموضوع:
      Date Created: 20241016 Date Completed: 20241016 Latest Revision: 20241023
    • الموضوع:
      20241023
    • الرقم المعرف:
      PMC11480968
    • الرقم المعرف:
      10.1002/ctm2.70051
    • الرقم المعرف:
      39412213