Relationship between platelet count and severity of neonatal respiratory distress syndrome.

Publisher: BioMed Central Country of Publication: England NLM ID: 101510759 Publication Model: Electronic Cited Medium: Internet ISSN: 1824-7288 (Electronic) Linking ISSN: 17208424 NLM ISO Abbreviation: Ital J Pediatr Subsets: MEDLINE

Original Publication: London : BioMed Central

Respiratory Distress Syndrome, Newborn*/blood ; Respiratory Distress Syndrome, Newborn*/therapy ; Thrombocytopenia*/blood ; Severity of Illness Index*; Humans ; Infant, Newborn ; Platelet Count ; Female ; Male ; Retrospective Studies ; Risk Factors ; Infant, Premature

Background: Neonatal respiratory distress syndrome (NRDS) is a primary cause of morbidity and mortality in premature infants. Platelets have a unique role in lung repair and remodeling. This study aimed to determine the relationship between platelet count and NRDS severity.
Methods: The study included 234 newborns diagnosed with NRDS from January 2019 to August 2023. This study employed two methods of grouping: the first based on platelet count, dividing participants into thrombocytopenia (platelet count < 150 × 10 ⁹ /L, n = 50) and non-thrombocytopenia groups (platelet count ≥ 150 × 10 ⁹ /L, n = 184), and the second based on the severity of NRDS, categorizing them into severe (n = 24) and mild-moderate (n = 210) groups. Within the first grouping method, the thrombocytopenia group was further subdivided into moderate-severe group (platelet count < 100 × 10 ⁹ /L, n = 4) and mild group (platelet count was between 100.0 × 10 ⁹ /L and 150.0 × 10 ⁹ /L, n = 46). This study aimed to analyze the clinical characteristics of NRDS with thrombocytopenia, explore the correlation between platelet count and clinical indicators of NRDS. Binary Logistic regression analysis was employed to identify independent risk factors for thrombocytopenia in NRDS.
Results: A higher proportion of newborns in the severe group exhibited thrombocytopenia (severe group = 41.7%, mild-moderate group = 19.0%). Hospital stay, ventilation time, oxygen therapy duration were longer in the thrombocytopenia group compared to the non-thrombocytopenia group. Hospital stay, ventilation time, oxygen therapy duration, chest radiography score, and C-reactive protein (CRP) levels were inversely associated with platelet count. Conversely, Apgar scores at 1 and 5 min, gestational age, and birth weight showed positive correlations with platelet count. Point-biserail correlation showed that thrombocytopenia was more likely to occur in newborns whose mothers had gestational hypertension, and the lower platelet count, the more severe NRDS. Oxygen therapy duration, birth weight < 1500 g, gestational hypertension and CRP levels emerged as independent risk factors for thrombocytopenia in NRDS. All differences were statistically significant (p all < 0.05).
Conclusion: NRDS accompanied by thrombocytopenia indicates a more severe condition and poorer clinical outcomes. It is hypothesized that NRDS with thrombocytopenia involves a complex multifactorial etiology, including severe lung inflammation.
(© 2024. The Author(s).)

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Keywords: NRDS; Platelet; Risk factor; Severity

Date Created: 20241008 Date Completed: 20241009 Latest Revision: 20241011

20241011

PMC11462692

10.1186/s13052-024-01762-2

39380088