Use of multiple micronutrient supplementation integrated into routine antenatal care: A discussion of research priorities.

Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101201025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-8709 (Electronic) Linking ISSN: 17408695 NLM ISO Abbreviation: Matern Child Nutr Subsets: MEDLINE

Publication: Oxford, UK : Wiley-Blackwell
Original Publication: Oxford, UK : Blackwell Pub., c2005-

Dietary Supplements* ; Micronutrients*/administration & dosage ; Prenatal Care*/methods; Female ; Humans ; Pregnancy ; Folic Acid/administration & dosage ; Maternal Nutritional Physiological Phenomena ; Research ; World Health Organization

Optimal maternal nutrition, including adequate intake and status of essential micronutrients, is important for the health of women and developing infants. Currently, the World Health Organization (WHO) Antenatal care recommendations for a positive pregnancy experience recommend daily iron and folic acid (IFA) supplementation as the standard of care. The use of multiple micronutrient supplements (MMS) is recommended in the context of rigorous research as more evidence was needed regarding the impact of switching from IFA supplements to MMS, including evaluation of critical clinical maternal and perinatal outcomes, acceptability, feasibility, sustainability, equity and cost-effectiveness. WHO convened a technical consultation of key stakeholders to discuss research priorities with the objective of providing guidance and clarity to donors, implementers and researchers about this recommendation. The overarching principles of the research agenda include the use of clinical indicators and impact measures that are applicable across studies and settings and the inclusion of outcomes that are important to women. Future studies should consider using standardized protocols based on current best practices to measure critical outcomes such as gestational age (GA) and birthweight (BW) in studies. As GA and BW are influenced by multiple factors, more research is needed to understand the biological impact pathways, and how initiation and considerations for timing of MMS influence these outcomes. A set of core clinical indicators was agreed upon during the technical consultation. For implementation research, the Evidence-to-Decision framework was used as a resource for discussing components of implementation research. The implementation research questions, key indicators and performance measures will depend on country-specific context and bottlenecks that require further research and improved solutions to enable the successful implementation of iron-containing supplements.
(© 2024 World Health Organization; licensed by John Wiley & Sons Ltd. Maternal & Child Nutrition published by John Wiley & Sons Ltd.)

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001 International WHO_ World Health Organization; Bill and Melinda Gates Foundation

Keywords: maternal nutrition; multiple micronutrient supplementation

935E97BOY8 (Folic Acid)
0 (Micronutrients)

Date Created: 20241002 Date Completed: 20241217 Latest Revision: 20241220

20241220

10.1111/mcn.13722

39356051