Comparative study on the anti-inflammatory and protective effects of different oxygen therapy regimens on lipopolysaccharide-induced acute lung injury in mice.

Publisher: STM Publishing Country of Publication: Australia NLM ID: 101564536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-9912 (Electronic) Linking ISSN: 20459912 NLM ISO Abbreviation: Med Gas Res Subsets: MEDLINE

Publication: 2015- : Willoughby, Australia : STM Publishing
Original Publication: London : BioMed Central

Acute Lung Injury*/therapy ; Acute Lung Injury*/chemically induced ; Acute Lung Injury*/metabolism ; Lipopolysaccharides* ; Mice, Inbred ICR* ; Hyperbaric Oxygenation*; Animals ; Mice ; Male ; Oxygen/metabolism ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/administration & dosage ; Lung/pathology ; Lung/metabolism

Oxygen therapy after acute lung injury can regulate the inflammatory response and reduce lung tissue injury. However, the optimal exposure pressure, duration, and frequency of oxygen therapy for acute lung injury remain unclear. In the present study, after intraperitoneal injection of lipopolysaccharide in ICR mice, 1.0 atmosphere absolute (ATA) pure oxygen and 2.0 ATA hyperbaric oxygen treatment for 1 hour decreased the levels of proinflammatory factors (interleukin-1beta and interleukin-6) in peripheral blood and lung tissues. However, only 2.0 ATA hyperbaric oxygen increased the mRNA levels of anti-inflammatory factors (interleukin-10 and arginase-1) in lung tissue; 3.0 ATA hyperbaric oxygen treatment had no significant effect. We also observed that at 2.0 ATA, the anti-inflammatory effect of a single exposure to hyperbaric oxygen for 3 hours was greater than that of a single exposure to hyperbaric oxygen for 1 hour. The protective effect of two exposures for 1.5 hours was similar to that of a single exposure for 3 hours. These results suggest that hyperbaric oxygen alleviates lipopolysaccharide-induced acute lung injury by regulating the expression of inflammatory factors in an acute lung injury model and that appropriately increasing the duration and frequency of hyperbaric oxygen exposure has a better tissue-protective effect on lipopolysaccharide-induced acute lung injury. These results could guide the development of more effective oxygen therapy regimens for acute lung injury patients.
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0 (Lipopolysaccharides)
S88TT14065 (Oxygen)
0 (Anti-Inflammatory Agents)

Date Created: 20240926 Date Completed: 20241022 Latest Revision: 20241226

20250114

PMC11515059

10.4103/mgr.MEDGASRES-D-24-00044

39324894