Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

The Effect of Monobenzone Cream on Oxidative Stress and Its Relationship With Serum Levels of IL-1β and IL-18 in Vitiligo Patients.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Blackwell Science Country of Publication: England NLM ID: 101130964 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2165 (Electronic) Linking ISSN: 14732130 NLM ISO Abbreviation: J Cosmet Dermatol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Oxford, UK : Blackwell Science, c2002-
    • الموضوع:
      Vitiligo*/blood ; Vitiligo*/drug therapy ; Oxidative Stress*/drug effects ; Interleukin-18*/blood ; Interleukin-1beta*/blood; Humans ; Male ; Adult ; Female ; Case-Control Studies ; Young Adult ; Hydroquinones/administration & dosage ; Hydroquinones/adverse effects ; Skin Cream/administration & dosage ; Skin Cream/adverse effects ; Middle Aged ; Adolescent ; Skin Pigmentation/drug effects ; Malondialdehyde/blood
    • نبذة مختصرة :
      Background: Monobenzyl ether hydroquinone (MEBHQ) is a cream that promotes the spread and evenness of skin patches in vitiligo. Our aim was to investigate the oxidative and inflammatory effects of this cream on vitiligo patients consuming MEBHQ.
      Methods: A case-control study was conducted with three groups of 30 people from the control group, vitiligo patients before and after treatment. The percentage of vitiligo spots was determined by a specialist doctor. The levels of biochemical factors, oxidative stress profile and inflammatory factors were measured by enzymatic, colorimetric and ELISA methods, respectively.
      Results: Vitiligo patients showed a high level of inflammation and oxidative stress compared to healthy people. Although after 3 months of using MBEHQ cream, the percentage of skin spots in vitiligo patients increased from an average of 63%-91% and the skin color became almost uniform, but it still increased the level of oxidative stress and inflammation in these patients. Although the level of oxidative stress increased significantly in these patients, there was no significant increase in the level of malondialdehyde. The lack of significant differences in the levels of biochemical factors between healthy people and vitiligo patients before and after using the treatment shows the absence of side effects.
      Conclusion: The use of MBEHQ increased the size of skin spots and uneven skin color in vitiligo patients. Although MBEHQ did not show side effects such as diabetes, liver and kidney diseases, it increased the levels of oxidative stress and inflammatory cytokines, which needs further study.
      (© 2024 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.)
    • References:
      J Am Acad Dermatol. 2011 Sep;65(3):473-491. (PMID: 21839315)
      Med Res Rev. 2021 Mar;41(2):1138-1166. (PMID: 33200838)
      Chin Med J (Engl). 2022 Apr 5;135(7):793-795. (PMID: 34935694)
      J Invest Dermatol. 1993 Aug;101(2):145-9. (PMID: 8345215)
      J Cutan Aesthet Surg. 2013 Apr;6(2):93-6. (PMID: 24023431)
      Arch Biochem Biophys. 2020 Dec 15;696:108670. (PMID: 33186606)
      Cells. 2023 Mar 19;12(6):. (PMID: 36980277)
      Oxid Med Cell Longev. 2022 Jan 19;2022:8796735. (PMID: 35096274)
      Int J Mol Sci. 2021 Oct 22;22(21):. (PMID: 34768860)
      J Dermatol. 2021 Mar;48(3):252-270. (PMID: 33404102)
      Pigment Cell Melanoma Res. 2011 Aug;24(4):673-9. (PMID: 21689385)
      J Clin Aesthet Dermatol. 2011 Jun;4(6):41-4. (PMID: 21779415)
      Oxid Med Cell Longev. 2020 Apr 23;2020:9829176. (PMID: 32411336)
      Int J Mol Sci. 2020 Nov 30;21(23):. (PMID: 33266350)
      J Invest Dermatol. 2011 Jun;131(6):1240-51. (PMID: 21326294)
      Science. 2014 Dec 19;346(6216):1536-40. (PMID: 25525252)
      Front Immunol. 2021 Jun 24;12:711080. (PMID: 34249018)
      Biomed Pharmacother. 2023 Apr;160:114364. (PMID: 36739764)
      Free Radic Res. 2017 Dec;51(11-12):986-994. (PMID: 29182456)
      Antioxidants (Basel). 2023 Apr 05;12(4):. (PMID: 37107258)
      Oxid Med Cell Longev. 2022 Jan 22;2022:8498472. (PMID: 35103096)
      Front Pharmacol. 2017 May 22;8:278. (PMID: 28588486)
      Front Immunol. 2021 Jun 09;12:714137. (PMID: 34177971)
      Cureus. 2022 Sep 18;14(9):e29307. (PMID: 36304341)
      Indian J Dermatol. 1972 Jan;17(2):51-6. (PMID: 5039893)
      Arch Pharm Res. 2021 Jan;44(1):16-35. (PMID: 33534121)
      J Eur Acad Dermatol Venereol. 2011 Jul;25(7):749-57. (PMID: 21054565)
      Clin Rev Allergy Immunol. 2021 Dec;61(3):299-323. (PMID: 34283349)
    • Contributed Indexing:
      Keywords: inflammation; malondialdehyde; monobenzyl ether of hydroquinone; oxidative stress; total oxidant status; vitiligo
    • الرقم المعرف:
      0 (Interleukin-18)
      9L2KA76MG5 (monobenzone)
      0 (Interleukin-1beta)
      0 (Hydroquinones)
      0 (IL18 protein, human)
      0 (IL1B protein, human)
      4Y8F71G49Q (Malondialdehyde)
    • الموضوع:
      Date Created: 20240924 Date Completed: 20241209 Latest Revision: 20241211
    • الموضوع:
      20241211
    • الرقم المعرف:
      PMC11626302
    • الرقم المعرف:
      10.1111/jocd.16544
    • الرقم المعرف:
      39313936