Beak and feather disease virus (BFDV) persists in tissues of asymptomatic wild Crimson Rosellas.

Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]-

Circoviridae Infections*/veterinary ; Circoviridae Infections*/virology ; Circovirus*/isolation & purification ; Circovirus*/genetics ; Circovirus*/physiology ; Bird Diseases*/virology ; Bird Diseases*/epidemiology; Animals ; Parrots/virology

Infectious diseases can drive populations and species to extinction. Beak and feather disease virus (BFDV) is a circovirus of global conservation concern that can infect all Psittaciformes and some other species. Yet some parrot species, such as Crimson rosellas (Platycercus elegans), can live successfully with high BFDV prevalence (>40%) with no clinical signs reported in infected individuals. We assessed BFDV load in 10-12 tissues per bird, from n = 66 P. elegans, to reveal tissue tropism and BFDV persistence in tissues. Here we show that in 94% of individuals, BFDV was detected in one or more tissues. While BFDV replicated to high levels in subadults, in adults (some confirmed seropositive) the virus persisted in various tissues at much lower levels. Our findings reveal that BFDV is much more common in wild P. elegans than previously thought and suggest that current screening practices (mostly on blood) may substantially underestimate BFDV infection estimates, with implications for biosecurity and conservation programs globally.
(© 2024. The Author(s).)

PLoS One. 2020 Jul 1;15(7):e0235406. (PMID: 32609774)
APMIS Suppl. 1990;14:1-32. (PMID: 2159766)
Aust Vet J. 2015 Dec;93(12):466-70. (PMID: 26769072)
Arch Virol. 2016 Aug;161(8):2059-74. (PMID: 27151279)
Vet Pathol. 2013 Nov;50(6):980-8. (PMID: 23482522)
Vet Microbiol. 2019 Aug;235:257-264. (PMID: 31383310)
Avian Pathol. 2005 Jun;34(3):227-32. (PMID: 16191706)
Arch Virol. 2015 Sep;160(9):2283-92. (PMID: 26138559)
J Wildl Dis. 2014 Apr;50(2):288-96. (PMID: 24484492)
Sci Rep. 2020 May 12;10(1):7894. (PMID: 32398741)
Aust Vet J. 2015 Aug;93(8):287-92. (PMID: 26220322)
Avian Dis. 2014 Sep;58(3):482-7. (PMID: 25518446)
Avian Pathol. 2000 Oct;29(5):373-94. (PMID: 19184829)
Aust Vet J. 1984 Mar;61(3):69-74. (PMID: 6743145)
J Med Microbiol. 2017 Jul;66(7):1005-1013. (PMID: 28703699)
J Vet Med B Infect Dis Vet Public Health. 2003 Oct;50(8):368-71. (PMID: 14633205)
J Vet Diagn Invest. 1990 Jul;2(3):204-7. (PMID: 2094445)
Science. 2019 Mar 29;363(6434):1459-1463. (PMID: 30923224)
Arch Virol. 2015 Jan;160(1):47-54. (PMID: 25209153)
Arch Virol. 2015 Jan;160(1):339-44. (PMID: 25193072)
PeerJ. 2020 Jun 11;8:e9211. (PMID: 32566393)
Curr Top Microbiol Immunol. 2009;331:151-83. (PMID: 19230563)
Avian Dis. 2000 Apr-Jun;44(2):470-8. (PMID: 10879931)
Avian Pathol. 1994 Dec;23(4):621-30. (PMID: 18671129)
Arch Virol. 2004 May;149(5):857-74. (PMID: 15098103)
J Avian Med Surg. 2009 Mar;23(1):53-63. (PMID: 19530408)
Aust Vet J. 1993 Apr;70(4):133-7. (PMID: 8494521)
J Virol. 1990 Jun;64(6):2768-79. (PMID: 2159543)
N Z Vet J. 2009 Feb;57(1):50-2. (PMID: 19252543)
Vet Microbiol. 2005 Dec 20;111(3-4):223-9. (PMID: 16289542)
J Vet Diagn Invest. 2001 Nov;13(6):475-82. (PMID: 11724137)
Sci Rep. 2015 Sep 28;5:14511. (PMID: 26411487)
J Virol. 2012 May;86(9):5221-9. (PMID: 22345474)
PeerJ. 2021 Dec 20;9:e12642. (PMID: 35036139)
J Wildl Dis. 2020 Oct 1;56(4):896-906. (PMID: 33600597)
PLoS One. 2014 Jan 08;9(1):e85370. (PMID: 24416396)
N Z Vet J. 2007 Oct;55(5):235-8. (PMID: 17928900)
Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14153-8. (PMID: 25225394)
N Z Vet J. 2014 Sep;62(5):297-301. (PMID: 24916448)
Virology. 2014 Jul;460-461:72-82. (PMID: 25010272)
Conserv Biol. 2018 Dec;32(6):1325-1335. (PMID: 30152576)
Arch Virol. 2012 Sep;157(9):1651-63. (PMID: 22638639)
Anim Health Res Rev. 2005 Dec;6(2):119-42. (PMID: 16583778)
Sci Rep. 2017 Oct 17;7(1):13310. (PMID: 29042596)
Microb Pathog. 2016 Jul;96:42-51. (PMID: 27165537)

Date Created: 20240917 Date Completed: 20240917 Latest Revision: 20241220

20241220

PMC11408594

10.1038/s42003-024-06652-1

39289466