Age-related analysis of corneal biomechanical parameters in healthy Chinese individuals.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Cornea*/physiology ; Cornea*/diagnostic imaging; Adolescent ; Adult ; Aged ; Child ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Age Factors ; Aging/physiology ; Biomechanical Phenomena ; China ; Cross-Sectional Studies ; East Asian People ; Healthy Volunteers ; Intraocular Pressure/physiology

To report the correlation between corneal biomechanical parameters and age in healthy Chinese individuals. This cross-sectional study was conducted on 864 eyes of 543 healthy participants. A comprehensive ophthalmic examination and corneal biomechanics examination using Corneal Visualization Scheimpflug Technology (Corvis ST) were conducted. Based on age, all participants were further divided into five age groups (n) as follows: group A, 11-20 years (105); group B, 21-30 years (112); group C, 31-40 years (113); group D, 41-50 years (100); and group E, > 50 years (113). Using Corvis ST, we examined 35 corneal biomechanical parameters and compared them across the different age groups. Spearman's correlation coefficients and stepwise multivariate linear regression models were used to investigate whether the corneal biomechanical parameters were related to demographic and ocular characteristics. A correlation analysis between the left and right eyes revealed that 13 parameters were significantly associated with eye differences. Among the 35 corneal biomechanical parameters, 28 exhibited significant differences across the age groups, with stiffness parameter at applanation 1(SPA1) showing an upward trend after the age of 30 and stress-strain index (SSI) demonstrates a statistically significant upward trend when comparing the five age groups in the study. Additionally, Spearman's correlation analysis and stepwise multivariate linear regression analysis revealed that 11 corneal biomechanical parameters were positively correlated with age and 10 were negatively correlated with age. Corvis biomechanical index (CBI) was significantly negatively correlated with intraocular pressure (IOP) and central corneal thickness (CCT), SSI was significantly positively correlated with age and IOP, and SPA1 were positively correlated with IOP and CCT. In conclusion, most corneal biomechanical parameters showed a significant correlation with age, with corneal stiffness progressively increasing alongside advancing age, IOP, or CCT.
(© 2024. The Author(s).)

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BHTR-KFJJ-202001 The Open Research Fund from Beijing Advanced Innovation Center for Big Data-Based Precision Medicine; 82171101 National Natural Science Foundation of China; Z181100006218099 Beijing Nova Program; 7242019 The Beijing Natural Science Foundation; 2024-2-1082 The Capital Health Research and Development of Special

Keywords: Age; Chinese; Corneal biomechanics; Corneal visualization Scheimpflug technology

Date Created: 20240917 Date Completed: 20240917 Latest Revision: 20241010

20241011

PMC11408652

10.1038/s41598-024-72054-2

39289420