Advancements in Plant-Based Therapeutics for Hepatic Fibrosis: Molecular Mechanisms and Nanoparticulate Drug Delivery Systems.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Liver Cirrhosis*/drug therapy ; Liver Cirrhosis*/metabolism ; Liver Cirrhosis*/pathology; Humans ; Animals ; Nanoparticle Drug Delivery System ; Drug Delivery Systems/methods ; Nanoparticles/chemistry ; Signal Transduction/drug effects ; Flavonoids/therapeutic use ; Flavonoids/administration & dosage ; Flavonoids/pharmacokinetics ; Polyphenols/therapeutic use ; Polyphenols/administration & dosage ; Polyphenols/chemistry

Chronic liver injuries often lead to hepatic fibrosis, a condition characterized by excessive extracellular matrix accumulation and abnormal connective tissue hyperplasia. Without effective treatment, hepatic fibrosis can progress to cirrhosis or hepatocellular carcinoma. Current treatments, including liver transplantation, are limited by donor shortages and high costs. As such, there is an urgent need for effective therapeutic strategies. This review focuses on the potential of plant-based therapeutics, particularly polyphenols, phenolic acids, and flavonoids, in treating hepatic fibrosis. These compounds have demonstrated anti-fibrotic activities through various signaling pathways, including TGF-β/Smad, AMPK/mTOR, Wnt/β-catenin, NF-κB, PI3K/AKT/mTOR, and hedgehog pathways. Additionally, this review highlights the advancements in nanoparticulate drug delivery systems that enhance the pharmacokinetics, bioavailability, and therapeutic efficacy of these bioactive compounds. Methodologically, this review synthesizes findings from recent studies, providing a comprehensive analysis of the mechanisms and benefits of these plant-based treatments. The integration of novel drug delivery systems with plant-based therapeutics holds significant promise for developing effective treatments for hepatic fibrosis.

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PN-III-P1-1.1-PD-2021-0327 (PD 94 ⁄ 2022) Romanian Ministry of Research and Innovation

Keywords: flavonoids; hepatic fibrosis; phenolic acids

0 (Nanoparticle Drug Delivery System)
0 (Flavonoids)
0 (Polyphenols)

Date Created: 20240914 Date Completed: 20240914 Latest Revision: 20240916

20240916

PMC11394827

10.3390/ijms25179346

39273295