Gold Nanoparticles for Retinal Molecular Optical Imaging.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Gold*/chemistry ; Metal Nanoparticles*/chemistry ; Optical Imaging*/methods ; Retina*/diagnostic imaging ; Retina*/metabolism ; Tomography, Optical Coherence*/methods; Humans ; Retinal Diseases/diagnostic imaging ; Retinal Diseases/diagnosis ; Animals ; Molecular Imaging/methods ; Contrast Media/chemistry

The incorporation of gold nanoparticles (GNPs) into retinal imaging signifies a notable advancement in ophthalmology, offering improved accuracy in diagnosis and patient outcomes. This review explores the synthesis and unique properties of GNPs, highlighting their adjustable surface plasmon resonance, biocompatibility, and excellent optical absorption and scattering abilities. These features make GNPs advantageous contrast agents, enhancing the precision and quality of various imaging modalities, including photoacoustic imaging, optical coherence tomography, and fluorescence imaging. This paper analyzes the unique properties and corresponding mechanisms based on the morphological features of GNPs, highlighting the potential of GNPs in retinal disease diagnosis and management. Given the limitations currently encountered in clinical applications of GNPs, the approaches and strategies to overcome these limitations are also discussed. These findings suggest that the properties and efficacy of GNPs have innovative applications in retinal disease imaging.

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R01 EY034325 United States EY NEI NIH HHS; 1R01EY033000 United States EY NEI NIH HHS; FFSGIA16002 Fight for Sight; 1K08EY027458 United States EY NEI NIH HHS; 1R01EY034325 United States EY NEI NIH HHS

Keywords: fluorescence imaging; gold nanoparticles; molecular imaging; optical coherence tomography; optical imaging; photoacoustic microscopy; retinal imaging

7440-57-5 (Gold)
0 (Contrast Media)

Date Created: 20240914 Date Completed: 20240914 Latest Revision: 20241119

20241119

PMC11395175

10.3390/ijms25179315

39273264