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HIV drug resistance: analysis of viral genotypes and mutation loci in people living with HIV in Chongqing, China (2016-2023).

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  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101237921 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-6405 (Electronic) Linking ISSN: 17426405 NLM ISO Abbreviation: AIDS Res Ther Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: [London] : BioMed Central, 2004-
    • الموضوع:
      HIV-1*/genetics ; HIV-1*/drug effects ; HIV Infections*/drug therapy ; HIV Infections*/virology ; HIV Infections*/epidemiology ; Drug Resistance, Viral*/genetics ; Genotype* ; Mutation* ; Anti-HIV Agents*/therapeutic use ; Anti-HIV Agents*/pharmacology; Humans ; China/epidemiology ; Retrospective Studies ; Male ; Female ; Adult ; Middle Aged ; Young Adult ; Reverse Transcriptase Inhibitors/therapeutic use ; Reverse Transcriptase Inhibitors/pharmacology ; Adolescent ; Aged
    • نبذة مختصرة :
      Background: Large-scale HIV genotype drug resistance study has not been conducted in Chongqing.
      Methods: A retrospective study was conducted on people living with HIV(PLWH) who received HIV-1 genotype resistance testing at Chongqing Public Health Medical Center from May 2016 to June 2023. The HIV-1pol gene was amplified through RT-PCR and analyzed in terms of genotypic drug resistance.
      Results: Of the 3015 PLWH tested for HIV-1 drug resistance, 1405 (46.6%) were resistant to at least one antiviral drug. Among non-nucleoside reverse transcriptase inhibitors (NNRTIs), 43.8% were resistant, compared to 29.5% for nucleoside reverse transcriptase inhibitors (NRTIs) and 3.4% for protease inhibitors (PIs). V179D/E and K103N/S were identified as the common mutation sites in the NNRTIs class of drugs, M184V/I and K65R/N were reported as the most common mutation sites in NRTIs, while thymidine analogue mutation (TAM) group was identified in 373 samples. L10FIV was the most common mutation in PIs. The dominant HIV-1 subtype was CRF07_BC.
      Conclusions: The high prevalence of HIV-1 drug resistance in Chongqing underscores the imperative for rigorous surveillance of the local HIV epidemic. Furthermore, TAMs are associated with HIV-1 multidrug resistance, and timely detection of drug resistance is helpful to reduce the emergence and spread of such drug-resistant strains.
      (© 2024. The Author(s).)
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    • Grant Information:
      202316 Technology Innovation and Application Development Project of Chongqing Shapingba District; 202316 Technology Innovation and Application Development Project of Chongqing Shapingba District; 2020FYYX112 Joint Medical Research Projects of Chongqing Municipal Health Committee and Chongqing Municipal Science and Technology Bureau; 2020FYYX112 Joint Medical Research Projects of Chongqing Municipal Health Committee and Chongqing Municipal Science and Technology Bureau; 2020FYYX112 Joint Medical Research Projects of Chongqing Municipal Health Committee and Chongqing Municipal Science and Technology Bureau; 2020FYYX112 Joint Medical Research Projects of Chongqing Municipal Health Committee and Chongqing Municipal Science and Technology Bureau
    • Contributed Indexing:
      Keywords: Drug resistance; Genotype; HIV-1; Thymidine analogue mutation
    • الرقم المعرف:
      0 (Anti-HIV Agents)
      0 (Reverse Transcriptase Inhibitors)
    • الموضوع:
      Date Created: 20240913 Date Completed: 20240914 Latest Revision: 20240916
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC11396324
    • الرقم المعرف:
      10.1186/s12981-024-00646-z
    • الرقم المعرف:
      39272106