A U-shaped association between selenium intake and cancer risk.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Selenium*/administration & dosage ; Selenium*/adverse effects ; Neoplasms*/epidemiology ; Neoplasms*/etiology; Humans ; Male ; Middle Aged ; Female ; Case-Control Studies ; Vietnam/epidemiology ; Risk Factors ; Aged ; Adult ; Odds Ratio ; Diet/adverse effects

While selenium is a cofactor of several antioxidant enzymes against cancer and is essential for human health, its excess intake may also be harmful. Though a safe intake of selenium has recently been recommended, it is not well understood in the Asian population. We aimed to determine the association between dietary intake of selenium and cancer risk in a case-control study of 3758 incident cancer cases (i.e., stomach, colon, rectum, lung cancers, and other sites) and 2929 control subjects in Vietnam. Daily intake of selenium was derived from a semiquantitative food frequency questionnaire. The unconditional logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for the association between selenium intake and cancer risk. We observed a U-shaped association between selenium intake and cancer risk. A safe intake ranged from 110.8 to 124.4 µg/day (mean 117.8 µg/day). Compared to individuals with the safe intake of selenium, individuals with the lowest intake (i.e., 27.8-77.2 µg/day) were associated with an increased risk of cancer (OR = 3.78, 95% CI 2.89-4.95) and those with the highest intake (169.1-331.7 µg/day) also had an increased cancer risk (OR = 1.86, 95% CI 1.45-2.39). A U-shaped pattern of association between selenium intake and cancer risk was stronger among participants with body mass index (BMI) < 23 kg/m ² and never smokers than BMI ≥ 23 kg/m ² and ever smokers (P's heterogeneity  = 0.003 and 0.021, respectively) but found in both never and ever-drinkers of alcohol (P heterogeneity  = 0.001). A U-shaped association between selenium intake and cancer risk was seen in cancer sites of the stomach, colon, rectum, and lung cancers. In summary, we found a U-shaped association between selenium intake and cancer risk and a safe selenium intake (mean: 117.8 µg/day) in the Vietnamese population. Further mechanistic investigation is warranted to understand better a U-shaped association between selenium intake and cancer risk.
(© 2024. The Author(s).)

Neurodegener Dis. 2017;17(4-5):171-180. (PMID: 28478440)
Eur J Epidemiol. 2016 Apr;31(4):337-50. (PMID: 27209009)
Cochrane Database Syst Rev. 2018 Jan 29;1:CD005195. (PMID: 29376219)
CRC Crit Rev Clin Lab Sci. 1973 Sep;4(3):215-340. (PMID: 4217238)
Br J Nutr. 2008 Aug;100(2):238-53. (PMID: 18346307)
Hered Cancer Clin Pract. 2019 Dec 23;17:33. (PMID: 31890061)
Acta Pharm. 2004 Dec;54(4):261-76. (PMID: 15634611)
Asian Pac J Cancer Prev. 2022 May 01;23(5):1587-1593. (PMID: 35633542)
Mol Med Rep. 2017 May;15(5):3323-3335. (PMID: 28339083)
Nutrients. 2015 May 13;7(5):3536-56. (PMID: 25984742)
Nutr Cancer. 2023;75(4):1243-1253. (PMID: 36927374)
Rev Environ Health. 2009 Jul-Sep;24(3):231-48. (PMID: 19891121)
Med Hypotheses. 2006;67(2):318-22. (PMID: 16574336)
Rev Environ Health. 2001 Jul-Sep;16(4):233-51. (PMID: 12041880)
J Trace Elem Electrolytes Health Dis. 1989 Sep;3(3):123-30. (PMID: 2535331)
BMC Cancer. 2015 Oct 07;15:657. (PMID: 26446998)
Am J Clin Nutr. 1993 May;57(5):662-5. (PMID: 8480683)
Crit Rev Food Sci Nutr. 2013;53(10):1077-96. (PMID: 23952089)
Epidemiology. 1996 Jul;7(4):384-90. (PMID: 8793364)
J Trace Elem Electrolytes Health Dis. 1994 Dec;8(3-4):159-65. (PMID: 7599506)
BMC Cancer. 2022 Aug 1;22(1):838. (PMID: 35915393)
Cell Biol Toxicol. 2012 Feb;28(1):31-46. (PMID: 21913064)
Biochim Biophys Acta. 2015 Aug;1850(8):1642-60. (PMID: 25459512)
Biochem J. 2001 Aug 1;357(Pt 3):851-8. (PMID: 11463357)
PLoS Med. 2009 Apr 7;6(4):e1000046. (PMID: 19360088)
Asian Pac J Cancer Prev. 2021 Sep 01;22(9):2903-2908. (PMID: 34582660)
Reprod Health. 2021 Apr 17;18(1):80. (PMID: 33865412)
Environ Res. 2022 Aug;211:113092. (PMID: 35259406)
Wien Klin Wochenschr. 2013 Mar;125(5-6):160-4. (PMID: 23508871)
J Biol Chem. 2003 Apr 18;278(16):13640-6. (PMID: 12574155)
Arch Intern Med. 2010 Feb 8;170(3):256-61. (PMID: 20142570)
Sci Rep. 2013;3:1425. (PMID: 23478344)
EFSA J. 2023 Jan 20;21(1):e07704. (PMID: 36698500)
West J Med. 1990 Aug;153(2):160-7. (PMID: 2219873)
Molecules. 2019 Apr 03;24(7):. (PMID: 30987088)
Clin Nutr. 2018 Oct;37(5):1675-1682. (PMID: 28778370)
Front Cardiovasc Med. 2021 Jul 30;8:671618. (PMID: 34395551)
Carcinogenesis. 2000 Aug;21(8):1531-6. (PMID: 10910955)
Asian Pac J Cancer Prev. 2022 Mar 01;23(3):861-865. (PMID: 35345357)
Carcinogenesis. 2013 May;34(5):1089-95. (PMID: 23389288)
Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):804-10. (PMID: 16614127)
Biol Trace Elem Res. 2019 Nov;192(1):26-37. (PMID: 31222623)

Keywords: Cancer risk; Case–control study; Dietary; Selenium intake; Vietnam

H6241UJ22B (Selenium)

Date Created: 20240913 Date Completed: 20240913 Latest Revision: 20240916

20240916

PMC11399399

10.1038/s41598-024-66553-5

39271688