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Diabetes mellitus in stable chronic heart failure and the combination with humoral activation, their association, and prediction of 2-year adverse outcomes. Data from the FAR NHL registry.

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  • معلومة اضافية
    • المصدر:
      Publisher: Blackwell Publishing Asia Country of Publication: Australia NLM ID: 101504326 Publication Model: Print Cited Medium: Internet ISSN: 1753-0407 (Electronic) Linking ISSN: 17530407 NLM ISO Abbreviation: J Diabetes Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Richmond, Vic. : Blackwell Publishing Asia, 2009-
    • الموضوع:
      Heart Failure*/blood ; Heart Failure*/physiopathology ; Registries* ; Diabetes Mellitus*/blood ; Diabetes Mellitus*/physiopathology ; Natriuretic Peptide, Brain*/blood; Humans ; Male ; Female ; Middle Aged ; Aged ; Prognosis ; Chronic Disease ; Prospective Studies ; Peptide Fragments/blood
    • نبذة مختصرة :
      Background/aim: The study aims to describe the role of diabetes in patients with heart failure.
      Methods: In all, 1052 chronic heart failure patients were included in the FARmacology and NeuroHumoral Activation (FAR NHL) multicenter prospective registry. They had ejection fraction below 50% and were on stable medication for at least 1 month.
      Results: More than one-third (38.9%) of the patients had diabetes mellitus (DM). Diabetic patients (N = 409) were older (median 67 vs. 64, p < 0.001), had higher body mass index (BMI) (30 vs. 28 kg/m 2 , p < 0.001), much more frequently had ischemic heart disease (71 vs. 47%, p < 0.001), hypertension (80 vs. 67%, p < 0.001), dyslipidemia (89 vs. 69%, p < 0.001), worse renal function (estimated glomerular filtration rate [eGFR] median 63 vs. 73 mL/min/1.73 m 2 , p < 0.001), and higher N-terminal pro-brain natriuretic peptide (NT-proBNP) (median 681 vs. 463 pg/mL, p = 0.003). All-cause death, left ventricle assist device implantation, and orthotopic heart transplantation were set as the combined primary end point, which was present in 15.5% (163 patients) within the 2-year follow-up. In the 2-year follow-up, 81.0% of patients with diabetes survived without a primary end point, while 85.4% of the patients without diabetes survived, the difference being on the verge of statistical significance (p = 0.089). DM is a statistically significant predictor of NT-proBNP value in univariate analysis, but it is not an independent predictor in a multivariate analysis. When the NT-proBNP level was high, the presence of DM did not influence the prognosis.
      Conclusion: The combination of diabetes and NT-proBNP levels may better stratify the prognosis of patients with chronic heart failure.
      (© 2024 The Author(s). Journal of Diabetes published by Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.)
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    • Contributed Indexing:
      Keywords: N‐terminal pro‐brain natriuretic peptide; chronic heart failure; diabetes mellitus; prognosis
    • الرقم المعرف:
      114471-18-0 (Natriuretic Peptide, Brain)
      0 (pro-brain natriuretic peptide (1-76))
      0 (Peptide Fragments)
    • الموضوع:
      Date Created: 20240912 Date Completed: 20240912 Latest Revision: 20241003
    • الموضوع:
      20241004
    • الرقم المعرف:
      PMC11391384
    • الرقم المعرف:
      10.1111/1753-0407.13605
    • الرقم المعرف:
      39263998