Acceptance and uptake of vaccines against tetanus, influenza, pertussis, and COVID-19 among pregnant and postpartum women in low- and middle-income countries: a systematic review and meta-analysis protocol.

Publisher: BioMed Central Country of Publication: England NLM ID: 101580575 Publication Model: Electronic Cited Medium: Internet ISSN: 2046-4053 (Electronic) Linking ISSN: 20464053 NLM ISO Abbreviation: Syst Rev Subsets: MEDLINE

Original Publication: London : BioMed Central

Systematic Reviews as Topic* ; COVID-19*/prevention & control ; Developing Countries* ; Influenza, Human*/prevention & control ; Tetanus*/prevention & control ; Meta-Analysis as Topic* ; SARS-CoV-2*/immunology ; Whooping Cough*/prevention & control; Humans ; Female ; Pregnancy ; Postpartum Period ; Pregnancy Complications, Infectious/prevention & control ; Vaccination/psychology ; COVID-19 Vaccines ; Patient Acceptance of Health Care ; Influenza Vaccines

Background: Pregnant women, fetuses, and neonates are particularly vulnerable to vaccine-preventable diseases (VPDs). These VPDs are associated with high morbidity and mortality among expectant mothers and their fetuses and neonates. Vaccination during pregnancy can protect the expectant mother from VPDs to which she may be especially vulnerable while pregnant. In addition, the passive transfer of maternal neutralizing immunoglobulin G (IgG) and secretory immunoglobulin A (IgA) also protects the fetus against congenital infections and may further protect the neonate from infection during the first few months of life. Despite this, coverage of recommended maternal vaccines remains suboptimal globally, especially in resource-constrained settings. Determinants of vaccine acceptance and uptake are frequently understudied in low- and middle-income countries (LMICs) and among specific groups such as pregnant and postpartum women. This proposed systematic review will assess the acceptance and uptake of vaccines against tetanus, influenza, pertussis, and COVID-19 among pregnant and postpartum women in LMICs.
Methods: A Boolean search strategy employing common and medical subject heading (MeSH) terms for tetanus, influenza, pertussis, and COVID-19 vaccines, as well as vaccine acceptance, hesitancy, together with uptake, pregnancy, and postpartum, will be used to search electronic databases for relevant literature published between 2009 and 2024. Only studies conducted in LMICs that investigated determinants of acceptance, hesitancy, and uptake of tetanus, influenza, pertussis, and COVID-19 vaccines among pregnant and postpartum women will be eligible for inclusion in the review. The quality and the risk of bias of all eligible full-text articles will be assessed using the Joanna Briggs Institute's (JBI) critical appraisal tools.
Discussion: This protocol proposes a systematic review and meta-analysis that aims to assess the uptake of maternal vaccines and to systematically appraise and quantify determinants of the acceptance and uptake of recommended vaccines during pregnancy and postpartum in LMICs. A better understanding of these factors and how they influence maternal vaccine decision-making will enable public health practitioners as well as global and national policymakers to design more effective interventions as we look towards expanding the scope and reach of maternal immunization programs.
(© 2024. The Author(s).)

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Keywords: Low- and middle-income countries; Maternal immunization; Postpartum; Vaccination in pregnancy; Vaccine acceptance; Vaccine uptake

0 (COVID-19 Vaccines)
0 (Influenza Vaccines)

Date Created: 20240905 Date Completed: 20240906 Latest Revision: 20240910

20240910

PMC11375862

10.1186/s13643-024-02645-7

39237969