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Primary neurolymphomatosis with MAG antibody: a case report.

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  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100968555 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2377 (Electronic) Linking ISSN: 14712377 NLM ISO Abbreviation: BMC Neurol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : BioMed Central, [2001-
    • الموضوع:
      Neurolymphomatosis*/diagnostic imaging ; Neurolymphomatosis*/diagnosis ; Myelin-Associated Glycoprotein*/immunology; Humans ; Male ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/complications ; Aged ; Autoantibodies/blood ; Autoantibodies/immunology ; Autoantibodies/cerebrospinal fluid
    • نبذة مختصرة :
      Neurolymphomatosis (NL) is a rare neurologic manifestation of non-Hodgkin lymphoma (NHL) with poor prognosis. Investigations including MRI, PET/CT, nerve biopsy and cerebrospinal fluid (CSF) analysis can aid the diagnosis of NL. In this study, we presented a case of NL with co-existing myelin-associated glycoprotein (MAG) antibody. The patient first presented with symptoms of peripheral neuropathy involving multiple cranial nerves and cauda equina, and later developed obstructive hydrocephalus and deep matter lesions. He also had persistently positive MAG antibody, but did not develop electrophysiologically proven neuropathy and monoclonal immunoglobulin. The final brain biopsy confirmed diffuse large B cell lymphoma.
      (© 2024. The Author(s).)
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    • Grant Information:
      No.202310152 the Jiangxi Provincial Health Commission science and technology plan; No.2022B563 the Science and Technology Plan of Jiangxi Provincial Administration of Traditional Chinese Medicine
    • Contributed Indexing:
      Keywords: Cranial neuropathy; MAG antibody; Neurolymphomatosis; Rituximab
    • الرقم المعرف:
      0 (Myelin-Associated Glycoprotein)
      0 (Autoantibodies)
    • الموضوع:
      Date Created: 20240905 Date Completed: 20240905 Latest Revision: 20241025
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC11375887
    • الرقم المعرف:
      10.1186/s12883-024-03798-7
    • الرقم المعرف:
      39237863