Research progress and application prospect of adipose-derived stem cell secretome in diabetes foot ulcers healing.

Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE

Original Publication: London : BioMed Central

Diabetic Foot*/therapy ; Diabetic Foot*/metabolism ; Diabetic Foot*/pathology ; Wound Healing* ; Adipose Tissue*/cytology ; Adipose Tissue*/metabolism ; Secretome*/metabolism; Humans ; Stem Cells/metabolism ; Stem Cells/cytology ; Animals

Diabetic foot ulcers (DFUs) are chronic wounds and one of the most common complications of diabetes, imposing significant physical and mental burdens on patients due to their poor prognosis and treatment efficacy. Adipose-derived stem cells (ADSCs) have been proven to promote wound healing, with studies increasingly attributing these beneficial effects to their paracrine actions. Consequently, research on ADSC secretome as a novel and promising alternative for DFU treatment has been extensively conducted. This article provides a comprehensive review of the mechanisms underlying refractory DFU wounds, the secretome of ADSCs, and its role in promoting wound healing in diabetes foot ulcers. And the review aims to provide reliable evidence for the clinical application of ADSC secretome in the treatment of refractory DFU wounds.
(© 2024. The Author(s).)

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2020GGB029 Young and Middle-aged Key Personnel Training Project of Fujian Provincial Health Commission; 2020Y9124 Joint Funds for the Innovation of Science and Technology, Fujian Province; 2021J01244 Natural Science Fundation of Fujian Province

Keywords: Adipose-derived stem cells; Diabetic foot ulcers; Secretome; Wound healing

Date Created: 20240903 Date Completed: 20240904 Latest Revision: 20240922

20240923

PMC11373215

10.1186/s13287-024-03912-z

39227906