The impact of intracytoplasmic sperm injection versus conventional in vitro fertilization on the reproductive outcomes of couples with non-male factor infertility and frozen-thawed embryo transfer cycles.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Sperm Injections, Intracytoplasmic*/methods ; Embryo Transfer*/methods ; Fertilization in Vitro*/methods; Humans ; Female ; Pregnancy ; Adult ; Retrospective Studies ; Male ; Cryopreservation/methods ; Pregnancy Outcome ; Infertility, Female/therapy ; Pregnancy Rate

This study was aimed to investigate the impact of intracytoplasmic sperm injection (ICSI) on reproductive outcomes in couples with non-male factor infertility and frozen-thawed embryo transfer (FET) treatment. This retrospective cohort study involved a total of 10,143 cycles from 6206 couples who underwent FET at the Third Affiliated Hospital of Zhengzhou University between January 2016 and September 2022. Patients were categorized into two groups based on the insemination methods of transferred embryos. Clinical and neonatal outcomes were compared between ICSI and conventional in vitro fertilization (cIVF) groups. The results showed that ICSI was not associated with improved clinical outcomes compared to cIVF. However, ICSI was associated with lower birthweight when twins were born. In conclusion, although subgroup analysis showed that ICSI was associated with slightly improved live birth rate for infertile couples with non-male factor infertility compared to cIVF, the regression analysis showed that ICSI did not demonstrate any improvement of the reproductive outcomes. The infertile women with twin pregnancies should be further informed of the lower birthweight and lower birth length when their oocytes were inseminated with ICSI. The findings of this study provide valuable insights for clinicians when discussing the benefits and risks of ICSI in patients with non-male factor infertility.
(© 2024. The Author(s).)

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LHGJ20190400 Joint Construction Project of Henan Medical Science and Technology Research Plan; LHGJ20200435 Joint Construction Project of Henan Medical Science and Technology Research Plan; 2021YFC2700602 National Key R&D Program "Fertility Health and Health Security for Women and Children"

Keywords: Frozen-thawed embryo transfer; Intracytoplasmic sperm injection; Non-male factor infertility; Preterm birth; Reproductive outcome

Date Created: 20240903 Date Completed: 20240903 Latest Revision: 20240906

20240906

PMC11372061

10.1038/s41598-024-71744-1

39227735