Weight Status, Autonomic Function, and Systemic Inflammation in Children with Obstructive Sleep Apnea.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Sleep Apnea, Obstructive*/physiopathology ; Inflammation*/blood ; Body Mass Index* ; Polysomnography*; Humans ; Male ; Female ; Child ; Heart Rate ; Cross-Sectional Studies ; Autonomic Nervous System/physiopathology ; Body Weight ; Interleukin-6/blood ; Child, Preschool ; Interleukin 1 Receptor Antagonist Protein/blood ; Interleukin-1beta/blood

Children with obstructive sleep apnea (OSA) frequently experience chronic low-grade systemic inflammation, with the inflammasome playing a central role in OSA. This cross-sectional study evaluated the relationship between weight status, autonomic function, and systemic inflammation in a cohort of 55 children with OSA, predominantly boys (78%) with an average age of 7.4 ± 2.2 years and an apnea-hypopnea index of 14.12 ± 17.05 events/hour. Measurements were taken of body mass index (BMI), sleep heart-rate variability, morning circulatory levels of interleukin-1β, interleukin-1 receptor antagonist, and interleukin-6, and tumor necrosis factor-α, anthropometry, and polysomnography. Multiple linear regression modeling showed that an apnea-hypopnea index was significantly associated with BMI, the standard deviation of successive differences between normal-to-normal intervals during N3 sleep, and the proportion of normal-to-normal interval pairs differing by more than 50 ms during rapid-eye-movement sleep. A moderated mediation model revealed that interleukin-1 receptor antagonist levels mediated the association between BMI and interleukin-6 levels, with sympathovagal balance during N3 sleep and minimum blood oxygen saturation further moderating these relationships. This study highlights the complex relationships between BMI, polysomnographic parameters, sleep heart-rate-variability metrics, and inflammatory markers in children with OSA, underlining the importance of weight management in this context.

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109-2314-B-182-083-MY3 National Science and Technology Council, Taiwan; CMRPG3F1091-3 Chang Gung Medical Foundation, Taiwan

Keywords: autonomic function; heart-rate variability; interleukin; mediation and moderation; obesity; obstructive sleep apnea; systemic inflammation

0 (Interleukin-6)
0 (Interleukin 1 Receptor Antagonist Protein)
0 (Interleukin-1beta)

Date Created: 20240829 Date Completed: 20240829 Latest Revision: 20240903

20240903

PMC11354383

10.3390/ijms25168951

39201638