Physical function is associated with cognitive status, brain amyloid-beta deposition, and blood biomarkers in Chinese Han population.

Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE

Original Publication: Oxford, UK : Wiley-Blackwell, c2008-

Amyloid beta-Peptides*/blood ; Amyloid beta-Peptides*/metabolism ; Biomarkers*/blood ; Brain*/metabolism ; Brain*/diagnostic imaging; Humans ; Female ; Male ; Aged ; Aged, 80 and over ; Middle Aged ; Cognition/physiology ; Cognitive Dysfunction/blood ; Positron Emission Tomography Computed Tomography ; Hand Strength/physiology ; China ; Neurofilament Proteins/blood ; East Asian People

Background: The physical function of elderly individuals reflects whether they have had a history of regular physical activity over the long term. Such indicators have been found to have a certain connection with cognitive function these years. However, there is limited research that associates it with mechanisms such as cerebral Aβ deposition. We aim to investigate this relationship and unveil the underlying mechanisms.
Method: Physical function and cognition data of 4189 participants were obtained from the Chinese preclinical Alzheimer's disease study. Participants were divided into six groups according to disease severity. Among them, 1048 participants underwent the positron emission tomography-computed tomography (PET-CT) and plasma biomarker test. Grip strength and gait were combined into a score indicating physical function. Multiple linear regression models and logistic regression models were mainly used to conduct the analysis.
Results: There was a significant positive correlation between physical function and cognitive function (R = 0.48, p < 0.001), independent of sex, age, apolipoprotein E-ε4 genotype, and disease stages (p < 0.001). Physical function was effective in distinguishing individuals with cognitive impairment from those without (AUC = 0.835). Physical function was negatively associated with brain Aβ deposition (p = 0.008) and brain Aβ had an intermediary effect (p < 0.01) on the association between physical function and cognition in women. This association was mainly evident in the lateral parietal, lateral temporal, posterior cingulate, frontal, occipital, and precuneus regions. Physical function was negatively associated with plasma neurofilament light-chain (Nfl) level (p < 0.001).
Conclusions: Physical function is strongly associated with cognitive function in the Chinese elderly, and brain Aβ deposition partly mediates the linkage in women. Plasma Nfl can be used as a potential target for exercise intervention in cognitive function. Improving physical function will contribute to the alleviation of cognition decline.
(© 2024 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.)

J Prev Alzheimers Dis. 2023;10(3):571-580. (PMID: 37357299)
Nat Commun. 2021 Jun 11;12(1):3555. (PMID: 34117234)
CNS Neurosci Ther. 2024 Aug;30(8):e14921. (PMID: 39155519)
Alzheimers Dement. 2023 Apr;19(4):1415-1427. (PMID: 36152312)
Lancet. 2011 Mar 19;377(9770):1019-31. (PMID: 21371747)
BMC Geriatr. 2019 Jul 5;19(1):186. (PMID: 31277579)
J Cachexia Sarcopenia Muscle. 2020 Apr;11(2):432-440. (PMID: 31912668)
Br J Sports Med. 2018 Feb;52(3):154-160. (PMID: 28438770)
Annu Rev Clin Psychol. 2017 May 8;13:369-396. (PMID: 28482688)
Neurol Neuroimmunol Neuroinflamm. 2021 Mar 29;8(3):. (PMID: 33782190)
J Am Geriatr Soc. 2020 Jul;68(7):1410-1418. (PMID: 32150289)
Mol Psychiatry. 2020 Nov;25(11):2728-2741. (PMID: 32518388)
Lancet Neurol. 2016 Jun;15(7):673-684. (PMID: 27068280)
Neuroepidemiology. 2007;29(3-4):156-62. (PMID: 18042999)
J Am Geriatr Soc. 1991 Feb;39(2):142-8. (PMID: 1991946)
Curr Alzheimer Res. 2020;17(6):517-525. (PMID: 32851945)
J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):929-35. (PMID: 17237140)
Am J Manag Care. 2020 Aug;26(8 Suppl):S177-S183. (PMID: 32840331)
Aging Ment Health. 2022 Feb;26(2):384-391. (PMID: 33533261)
Ageing Res Rev. 2020 Mar;58:101022. (PMID: 31996326)
Blood. 2019 Jul 25;134(4):374-382. (PMID: 31167800)
Ageing Res Rev. 2015 Sep;23(Pt B):193-209. (PMID: 26219494)
Lancet. 2019 Jun 29;393(10191):2636-2646. (PMID: 31171417)
J Am Med Dir Assoc. 2016 Dec 1;17(12):1164.e7-1164.e15. (PMID: 27816484)
Int J Cardiol. 2016 Jul 15;215:487-93. (PMID: 27131770)
J Prev Alzheimers Dis. 2018;5(4):225-230. (PMID: 30298180)
BMJ. 2023 Jan 25;380:e072691. (PMID: 36696990)
Alzheimers Dement. 2018 Sep;14(9):1171-1183. (PMID: 29907423)
Front Aging Neurosci. 2022 Oct 31;14:1026688. (PMID: 36389059)
Brain. 2023 Jun 1;146(6):2268-2274. (PMID: 37127299)
EBioMedicine. 2016 Jul;9:1-2. (PMID: 27412262)
J Frailty Aging. 2021;10(2):141-149. (PMID: 33575703)
Healthcare (Basel). 2022 Oct 17;10(10):. (PMID: 36292500)
Ageing Res Rev. 2022 Apr;76:101591. (PMID: 35182742)
Front Endocrinol (Lausanne). 2021 May 20;12:660181. (PMID: 34093436)
J Nucl Med. 2016 Aug;57(8):1316-22. (PMID: 27481605)
J Gerontol A Biol Sci Med Sci. 2013 Nov;68(11):1395-401. (PMID: 23902934)
JAMA Neurol. 2017 May 1;74(5):557-566. (PMID: 28346578)
Neurology. 1993 Nov;43(11):2412-4. (PMID: 8232972)
Eur Arch Psychiatry Clin Neurosci. 1999;249(6):288-90. (PMID: 10653284)
Alzheimers Dement. 2011 May;7(3):263-9. (PMID: 21514250)
Nature. 2011 Jul 13;475(7355):S1. (PMID: 21760574)
Stroke. 2012 Feb;43(2):464-9. (PMID: 22156700)
Lancet Neurol. 2021 Mar;20(3):222-234. (PMID: 33609479)
Alzheimers Dement (Amst). 2022 Sep 22;14(1):e12353. (PMID: 36187193)
Am J Manag Care. 2022 Sep;28(10 Suppl):S188-S196. (PMID: 36197132)
BMJ. 2018 May 16;361:k1675. (PMID: 29769247)

21YJC890030 Humanities and Social Sciences Youth Fund of Ministry of Education; ZJLab; 31972935 National Natural Science Foundation of China; 82171198 National Natural Science Foundation of China; 2019YFA0802301 National Key Research and Development Program of China; 2018SHZDZX01 Shanghai Municipal Science and Technology Major Project

Keywords: Alzheimer's disease; cognitive function; gait; grip strength; physical function

0 (Amyloid beta-Peptides)
0 (Biomarkers)
0 (Neurofilament Proteins)
0 (neurofilament protein L)

Date Created: 20240819 Date Completed: 20240819 Latest Revision: 20241028

20241028

PMC11330986

10.1111/cns.14921

39155519