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Association between kidney function and Parkinson's disease risk: a prospective study from the UK Biobank.

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  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100968562 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2458 (Electronic) Linking ISSN: 14712458 NLM ISO Abbreviation: BMC Public Health Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : BioMed Central, [2001-
    • الموضوع:
      Glomerular Filtration Rate*/physiology ; Parkinson Disease*/epidemiology ; Parkinson Disease*/physiopathology; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Cystatin C/blood ; Prospective Studies ; Risk Factors ; UK Biobank ; United Kingdom/epidemiology
    • نبذة مختصرة :
      Background: Parkinson's disease (PD) is a neurodegenerative influenced by various clinical factors. The potential relationship between renal function and the risk of PD remains poorly understood. This study aims to explore the association between kidney function and the risk of developing PD.
      Methods: A population-based cohort study was conducted using data from 400,571 UK Biobank participants. Renal function was assessed using the estimated glomerular filtration rate (eGFR), calculated from serum creatinine and cystatin C levels. The association between eGFR levels and PD risk was evaluated using univariate and multivariate Cox regression analyses, Restricted Cubic Spline (RCS) analysis, and Kaplan-Meier analysis. Additionally, a clinical prediction model was developed and its diagnostic accuracy was evaluated using ROC analysis. A heatmap was also constructed to examine the relationship between clinical factors and gray matter volume in various brain regions.
      Results: Over a median observation period of 13.8 years, 2740 PD events were recorded. Cox regression and Kaplan-Meier analyses revealed a significant association between decreased eGFR and increased PD risk, particularly in participants with eGFR < 30 ml/min/1.73 m 2 . This association was confirmed across three adjusted models. RCS analysis demonstrated a nonlinear relationship between decreasing eGFR and increasing PD risk. Furthermore, changes in eGFR were correlated with alterations in subcortical gray matter volume in regions such as the frontal cortex, striatum, and cerebellum. The clinical prediction model showed high diagnostic accuracy with AUC values of 0.776, 0.780, and 0.824 for 4-, 8-, and 16-year predictions, respectively.
      Conclusion: Renal insufficiency is significantly associated with an increased risk of PD, highlighting the importance of maintaining good kidney function as a potential preventive measure against PD.
      (© 2024. The Author(s).)
    • References:
      Hemodial Int. 2018 Apr;22(2):150-160. (PMID: 28799704)
      BMC Geriatr. 2020 Oct 2;20(Suppl 1):350. (PMID: 33008303)
      Kidney Blood Press Res. 2022;47(8):493-505. (PMID: 35378538)
      Neurobiol Dis. 2020 Feb;134:104671. (PMID: 31706021)
      Mol Neurobiol. 2022 Sep;59(9):5516-5531. (PMID: 35732866)
      N Engl J Med. 2012 Jul 5;367(1):20-9. (PMID: 22762315)
      Pediatr Nephrol. 2021 Oct;36(10):2997-3006. (PMID: 33411069)
      Mov Disord Clin Pract. 2020 Oct 01;7(8):994-995. (PMID: 33163574)
      Lancet Neurol. 2021 May;20(5):385-397. (PMID: 33894193)
      Mov Disord Clin Pract. 2020 Aug 10;7(7):763-779. (PMID: 33043074)
      Hypertens Res. 2021 Jun;44(6):605-617. (PMID: 33526913)
      Neurology. 2017 Jan 10;88(2):198-208. (PMID: 27974647)
      Nutrients. 2023 Jul 19;15(14):. (PMID: 37513623)
      Free Radic Biol Med. 2021 Aug 20;172:530-540. (PMID: 34174395)
      Metab Brain Dis. 2021 Jan;36(1):1-12. (PMID: 32990929)
      Life Sci. 2023 Apr 15;319:121432. (PMID: 36706833)
      Kidney Dis (Basel). 2022 May 3;8(4):275-285. (PMID: 36157262)
      Neurosci Bull. 2023 Jan;39(1):113-124. (PMID: 35994167)
      Eur Rev Med Pharmacol Sci. 2015 Jun;19(12):2275-81. (PMID: 26166654)
      Eur J Hum Genet. 2023 Mar;31(3):313-320. (PMID: 35853950)
      Metab Brain Dis. 2016 Apr;31(2):481-4. (PMID: 26631408)
      Transl Stroke Res. 2020 Feb;11(1):122-134. (PMID: 31055735)
      Int J Mol Sci. 2021 Nov 26;22(23):. (PMID: 34884606)
      Am J Kidney Dis. 2022 Feb;79(2):268-288.e1. (PMID: 34563581)
      JAMA. 2020 Feb 11;323(6):548-560. (PMID: 32044947)
      Signal Transduct Target Ther. 2022 Jun 9;7(1):182. (PMID: 35680856)
      Mov Disord. 2020 Mar;35(3):519. (PMID: 32166802)
      J Am Coll Cardiol. 2021 Jul 6;78(1):56-65. (PMID: 34210415)
      J Stroke Cerebrovasc Dis. 2021 Sep;30(9):105404. (PMID: 33272863)
      Mov Disord. 2019 Aug;34(8):1184-1191. (PMID: 31021467)
      Biol Psychiatry. 2021 May 1;89(9):839-841. (PMID: 33858589)
      Neurol Res. 2023 May;45(5):456-464. (PMID: 36692889)
      Neuroepidemiology. 2014;42(4):204-10. (PMID: 24751820)
    • Grant Information:
      SYLYC2023155 the Project of Action for Postgraduate Training Innovation and Quality Improvement of Henan University; SBGJ202102035 Henan Medical Science and technology research program; 2024ZY2133 the Henan Province Traditional Chinese Medicine Science Research Special Project
    • Contributed Indexing:
      Keywords: Chronic kidney disease; Estimated glomerular filtration rate; Kidney function; Parkinson’s disease; UK Biobank
    • الرقم المعرف:
      0 (Cystatin C)
    • الموضوع:
      Date Created: 20240815 Date Completed: 20240815 Latest Revision: 20240819
    • الموضوع:
      20240820
    • الرقم المعرف:
      PMC11328353
    • الرقم المعرف:
      10.1186/s12889-024-19709-x
    • الرقم المعرف:
      39148063