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The influence of contrast media on calcium-based imaging of the spine in dual-layer CT.

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  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Contrast Media*/chemistry ; Tomography, X-Ray Computed*/methods ; Calcium*/metabolism ; Bone Density*/drug effects; Humans ; Female ; Male ; Aged ; Middle Aged ; Lumbar Vertebrae/diagnostic imaging ; Aged, 80 and over ; Spine/diagnostic imaging ; Adult ; Osteoporosis/diagnostic imaging
    • نبذة مختصرة :
      This study aimed to evaluate the impact of contrast media application on CT attenuation of the bone using a novel calcium-only imaging technique (VCa) from dual-layer spectral detector CT (DLCT), which enables CT-based bone mineral density measurement unimpeded by soft tissue components. For this, true non-contrast (TNC) and venous phase images (VP) of n = 97 patients were acquired. CT attenuation of the first lumbar vertebra (L1) was measured in TNC-VCa, VP-VCa, and in virtual non-contrast images (VNC). CT attenuation was significantly higher in VP-VCa than in TNC-VCa (p < 0.001), although regression analyses revealed a strong linear association between these measures (R 2  = 0.84). A statistical model for the prediction of TNC-VCa CT attenuation was established (TNC-VCa[HU] = - 6.81 + 0.87 × VP-VCa[HU]-0.55 × body weight[kg]) and yielded good agreement between observed and predicted values. Furthermore, a L1 CT attenuation threshold of 293 HU in VP-VCa showed a sensitivity of 90% and a specificity of 96% for detecting osteoporosis. The application of contrast media leads to an overestimation of L1 CT attenuation in VCa. However, CT attenuation values from VP-VCa can be used within CT-based opportunistic osteoporosis screening eighter by applying a separate threshold of 293 HU or by converting measured data to TNC-VCa CT attenuation with the given regression equation.
      (© 2024. The Author(s).)
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    • Contributed Indexing:
      Keywords: Computed tomography; Contrast media; Dual-layer spectral CT; Virtual non-calcium
    • الرقم المعرف:
      0 (Contrast Media)
      SY7Q814VUP (Calcium)
    • الموضوع:
      Date Created: 20240814 Date Completed: 20240814 Latest Revision: 20240817
    • الموضوع:
      20240817
    • الرقم المعرف:
      PMC11324893
    • الرقم المعرف:
      10.1038/s41598-024-69743-3
    • الرقم المعرف:
      39143146