Advanced Application of Polymer Nanocarriers in Delivery of Active Ingredients from Traditional Chinese Medicines.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, c1995-

Medicine, Chinese Traditional* ; Polymers*/chemistry ; Drug Carriers*/chemistry ; Nanoparticles*/chemistry ; Drugs, Chinese Herbal*/chemistry ; Drugs, Chinese Herbal*/pharmacokinetics; Humans ; Drug Delivery Systems ; Animals ; Biological Availability ; Micelles

Active ingredients from Traditional Chinese Medicines (TCMs) have been a cornerstone of healthcare for millennia, offering a rich source of bioactive compounds with therapeutic potential. However, the clinical application of TCMs is often limited by challenges such as poor solubility, low bioavailability, and variable pharmacokinetics. To address these issues, the development of advanced polymer nanocarriers has emerged as a promising strategy for the delivery of TCMs. This review focuses on the introduction of common active ingredients from TCMs and the recent advancements in the design and application of polymer nanocarriers for enhancing the efficacy and safety of TCMs. We begin by discussing the unique properties of TCMs and the inherent challenges associated with their delivery. We then delve into the types of polymeric nanocarriers, including polymer micelles, polymer vesicles, polymer hydrogels, and polymer drug conjugates, highlighting their application in the delivery of active ingredients from TCMs. The main body of the review presents a comprehensive analysis of the state-of-the-art nanocarrier systems and introduces the impact of these nanocarriers on the solubility, stability, and bioavailability of TCM components. On the basis of this, we provide an outlook on the future directions of polymer nanocarriers in TCM delivery. This review underscores the transformative potential of polymer nanocarriers in revolutionizing TCM delivery, offering a pathway to harness the full therapeutic potential of TCMs while ensuring safety and efficacy in a modern medical context.

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2022A1515010624 Natural Science Foundation of Guangdong Province

Keywords: Traditional Chinese Medicines; drug delivery; polymer drug conjugates; polymer hydrogels; polymer micelles; polymer vesicles

0 (Polymers)
0 (Drug Carriers)
0 (Drugs, Chinese Herbal)
0 (Micelles)

Date Created: 20240810 Date Completed: 20240810 Latest Revision: 20240812

20240813

PMC11314021

10.3390/molecules29153520

39124924