Regional brain activity and connectivity associated with childhood trauma in drug-naive patients with obsessive-compulsive disorder.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Obsessive-Compulsive Disorder*/physiopathology ; Obsessive-Compulsive Disorder*/diagnostic imaging ; Magnetic Resonance Imaging* ; Brain*/physiopathology ; Brain*/diagnostic imaging; Humans ; Male ; Female ; Adult ; Cerebellum/physiopathology ; Cerebellum/diagnostic imaging ; Brain Mapping ; Young Adult ; Case-Control Studies

Obsessive-compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive, compulsive behaviors, with childhood trauma recognized as a contributing factor to its pathophysiology. This study aimed to delineate brain functional aberrations in OCD patients and explore the association between these abnormalities and childhood trauma, to gain insights into the neural underpinnings of OCD. Forty-eight drug-naive OCD patients and forty-two healthy controls (HC) underwent resting-state functional magnetic resonance imaging and clinical assessments, including the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Childhood Trauma Questionnaire-Short Form (CTQ-SF). Compared to HCs, OCD patients exhibited significantly decreased amplitude of low-frequency fluctuations (ALFF) in the right cerebellum, decreased regional homogeneity (ReHo) in the right cerebellum and right superior occipital lobes (FWE-corrected p < 0.05), which negatively correlated with Y-BOCS scores (p < 0.05). Furthermore, cerebellar ALFF negatively correlated with the CTQ emotional abuse subscale (r = - 0.514, p < 0.01). Mediation analysis revealed that cerebellar ALFF mediated the relationship between CTQ-emotional abuse and Y-BOCS (good model fit: R2 = 0.231, MSE = 14.311, F = 5.721, p < 0.01; direct effect, c' = 0.153, indirect effect, a*b = 0.191). Findings indicated abnormal spontaneous and regional cerebellar activity in OCD, suggesting childhood trauma impacts OCD symptoms through cerebellar neural remodeling, highlighting its importance for clinical treatment selection.
(© 2024. The Author(s).)

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2022AAC02067 Natural Science Foundation of Ningxia Program

Keywords: Amplitude of low-frequency fluctuation; Childhood trauma; Obsessive–compulsive disorder; Regional homogeneity; Resting-state functional connectivity

Date Created: 20240805 Date Completed: 20240805 Latest Revision: 20240812

20240813

PMC11300583

10.1038/s41598-024-69122-y

39103500