Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

An Unusual Cause of Lymphadenopathy: Rosai Dorfman Disease in a 7-Year-Old Female Zambian Child: Case Report and Literature Review.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: SAGE Publications Country of Publication: United States NLM ID: 101531893 Publication Model: eCollection Cited Medium: Print ISSN: 1179-5476 (Print) Linking ISSN: 11795476 NLM ISO Abbreviation: Clin Med Insights Case Rep Subsets: PubMed not MEDLINE
    • بيانات النشر:
      Publication: <2016- > : Thousand Oaks, CA : SAGE Publications
      Original Publication: Auckland, N.Z. : Libertas Academica
    • نبذة مختصرة :
      Rosai Dorfman disease (RDD) is a rare non-Langerhans histiocytic disorder, which belongs to the R group of the 2016 revised histiocytic classification. It's characterized by the accumulation of activated histiocytes in the sinusoids of lymph nodes and/or extranodal tissues. Herein, we report a 7-year-old female who was initially suspected to have a lymphoma but was later identified as having RDD. She presented with a history of fever, night sweats, and weight loss, and on physical examination had bilateral cervical lymphadenopathy. Histologic examination of the biopsied cervical lymph nodes showed distended sinuses with S100 and CD68 immunoreactive histiocytes demonstrating emperipolesis, confirming a diagnosis of RDD. The condition is known to be self-limiting. However, evidence from literature and our case management shows that medical therapy can hasten remission in pediatric cases.
      Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
      (© The Author(s) 2024.)
    • References:
      Case Rep Pediatr. 2022 May 26;2022:9571400. (PMID: 35664545)
      Cureus. 2023 Feb 19;15(2):e35193. (PMID: 36960255)
      Radiol Case Rep. 2023 Dec 20;19(3):956-960. (PMID: 38204935)
      Saudi Med J. 2022 Apr;43(4):341-347. (PMID: 35414611)
      Int J Infect Dis. 2008 Mar;12(2):219-21. (PMID: 17714970)
      Clin Case Rep. 2021 Sep 21;9(9):e04795. (PMID: 34584701)
      BMC Pediatr. 2016 May 03;16:62. (PMID: 27142277)
      Blood. 2016 Jun 2;127(22):2672-81. (PMID: 26966089)
      Clin Case Rep. 2020 Aug 26;8(12):2712-2715. (PMID: 33363810)
      Cent Eur J Immunol. 2018;43(3):341-345. (PMID: 30588179)
      Blood. 2018 Jun 28;131(26):2877-2890. (PMID: 29720485)
      Pan Afr Med J. 2023 Jul 18;45:130. (PMID: 37790150)
      Orphanet J Rare Dis. 2022 Mar 2;17(1):92. (PMID: 35236371)
    • Contributed Indexing:
      Keywords: Rosai-Dorfman disease; Zambia; histiocytosis; histopathology; massive lymphadenopathy
    • الموضوع:
      Date Created: 20240801 Latest Revision: 20240802
    • الموضوع:
      20240802
    • الرقم المعرف:
      PMC11289797
    • الرقم المعرف:
      10.1177/11795476241265279
    • الرقم المعرف:
      39086600