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Cerebral homeostasis and orthostatic responses in residents of the highest city in the world.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Homeostasis* ; Altitude Sickness*/physiopathology ; Altitude* ; Blood Pressure*/physiology ; Heart Rate*/physiology ; Baroreflex*/physiology ; Cerebrovascular Circulation*/physiology; Humans ; Male ; Adult ; Middle Aged ; Blood Flow Velocity ; Middle Cerebral Artery/physiopathology ; Hypoxia/physiopathology
    • نبذة مختصرة :
      Permanent residence at high-altitude and chronic mountain sickness (CMS) may alter the cerebrovascular homeostasis and orthostatic responses. Healthy male participants living at sea-level (LL; n = 15), 3800 m (HL 3800m ; n = 13) and 5100 m (HL 5100m ; n = 17), respectively, and CMS highlanders living at 5100 m (n = 31) were recruited. Middle cerebral artery mean blood flow velocity (MCAv), cerebral oxygen delivery (CDO 2 ), mean blood pressure (MAP), heart rate variability and spontaneuous cardiac baroreflex sensitivity (cBRS) were assessed while sitting, initial 30 s and after 3 min of standing. Cerebral autoregulation index (ARI) was estimated (ΔMCAv %baseline )/ΔMAP %baseline ) in response to the orthostatic challenge. Altitude and CMS were associated with hypoxemia and elevated hemoglobin concentration. While sitting, MCAv and LF power negatively correlated with altitude but were not affected by CMS. CDO 2 remained preserved. BRS was comparable across all altitudes, but lower with CMS. Within initial 30 s of standing, altitude and CMS correlated with a lesser ΔMAP while ARI remained unaffected. After 3 min standing, MCAv, CDO 2 and cBRS remained preserved across altitudes. The LF/HF ratio increased in HL 5100m compared to LL and HL 3800m from sitting to standing. In contrary, CMS showed blunted autonomic nervous activation in responses to standing. Despite altitude- and CMS-associated hypoxemia, erythrocytosis and impaired blood pressure regulation (CMS only), cerebral homeostasis remained overall preserved.
      (© 2024. The Author(s).)
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    • Grant Information:
      P5R5PM_210361 Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; ANR-15-IDEX-02 Commissariat Général à l'Investissement; ANR-12-TECS-0010 Agence Nationale de la Recherche
    • الموضوع:
      Date Created: 20240731 Date Completed: 20240731 Latest Revision: 20240808
    • الموضوع:
      20240808
    • الرقم المعرف:
      PMC11291767
    • الرقم المعرف:
      10.1038/s41598-024-68389-5
    • الرقم المعرف:
      39085313