Enhanced skin regeneration and therapeutic delivery using novel diamond-augmented zinc oxide.

Publisher: Blackwell Science Country of Publication: England NLM ID: 101130964 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2165 (Electronic) Linking ISSN: 14732130 NLM ISO Abbreviation: J Cosmet Dermatol Subsets: MEDLINE

Original Publication: Oxford, UK : Blackwell Science, c2002-

Zinc Oxide*/administration & dosage ; Fibroblasts*/drug effects ; Wound Healing*/drug effects ; Niacinamide*/administration & dosage ; Niacinamide*/pharmacology ; Regeneration*/drug effects ; Administration, Cutaneous* ; Collagen*; Humans ; Skin Absorption/drug effects ; Female ; Skin/drug effects ; Cell Movement/drug effects ; Middle Aged ; Cells, Cultured ; Lasers, Gas/therapeutic use ; Aged

Background: Recent advancements in dermatological therapeutics have highlighted the need for treatments that enhance skin regeneration and healing. Diamond-Augmented Zinc Oxide (ND-ZnO) technology combines zinc oxide with diamond particles in a unique core-shell structure, offering a multifaceted approach to overall skin health.
Aims: This study evaluates the efficacy of ND-ZnO in promoting human dermal fibroblast migration and growth, enhancing total collagen synthesis, and improving transdermal delivery of active ingredients as a daily comprehensive skin regeneration topical therapy.
Patients/methods: In vitro assays assessed wound healing, collagen production, and skin absorption. Human Dermal Fibroblasts (HDFs) were used in scratch wound assays. Collagen synthesis was quantified using enzyme-linked immunosorbent assays (ELISA). Permeation tests were performed on reconstructed human epidermal tissues to evaluate niacinamide absorption. Clinical case studies validated ND-ZnO efficacy in post-CO ₂ laser treatments and Actinic Keratosis removal recovery.
Results: ND-ZnO increased HDF migration by 198% compared to controls. Collagen synthesis assays showed a 71.3% restoration of collagen production in aged HDFs. Skin permeation studies revealed a 203% increase in niacinamide skin absorption with ND-ZnO. Clinical case studies demonstrated faster and more effective healing post-ablative CO₂ laser and significant improvements in Actinic Keratosis recovery.
Conclusions: ND-ZnO technology enhances wound healing, collagen synthesis, and active ingredient delivery, offering substantial benefits for daily skin regeneration and other dermatological applications. This innovative approach holds promise for advancing dermatological therapeutics, providing comprehensive skin care solutions that address both protective and regenerative needs.
(© 2024 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.)

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B.A.I. Biosciences.

Keywords: collagen synthesis; dermatological therapeutics; diamond‐augmented zinc oxide; skin regeneration; wound healing

SOI2LOH54Z (Zinc Oxide)
25X51I8RD4 (Niacinamide)
9007-34-5 (Collagen)

Date Created: 20240731 Date Completed: 20241209 Latest Revision: 20241211

20250114

PMC11626335

10.1111/jocd.16508

39083431