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Depression prevalence of the Geriatric Depression Scale-15 was compared to Structured Clinical Interview for DSM using individual participant data meta-analysis.

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  • معلومة اضافية
    • Corporate Authors:
      DEPRESsion Screening Data (DEPRESSD) GDS Group
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Depression*/epidemiology ; Depression*/diagnosis ; Diagnostic and Statistical Manual of Mental Disorders* ; Psychiatric Status Rating Scales*; Humans ; Prevalence ; Aged ; Female ; Male ; Geriatric Assessment/methods ; Aged, 80 and over ; Depressive Disorder, Major/epidemiology ; Depressive Disorder, Major/diagnosis
    • نبذة مختصرة :
      Depression questionnaire cutoffs are calibrated for screening accuracy and not to assess prevalence, but the Geriatric Depression Scale (GDS-15) is often used to estimate diagnostic prevalence among older adults, most commonly with scores of ≥ 5. We conducted an individual participant data meta-analysis to compare depression prevalence based on GDS-15 ≥ 5 to Structured Clinical Interview for Diagnostic and Statistical Manual (SCID) diagnoses and assessed whether an alternative cutoff could be more accurate. We used generalized linear mixed models to estimate prevalence. Data from 14 studies (3602 participants, 434 SCID major depression) were included. Pooled GDS-15 ≥ 5 prevalence was 34.2% (95% confidence interval [CI] 27.5-41.6%), and pooled SCID prevalence was 14.8% (95% CI 10.0-21.5%; difference of 17.6%, 95% CI 11.6-23.6%). GDS-15 ≥ 8 provided the closest estimate to SCID with mean difference of - 0.3% (95% prediction interval - 17.0-16.5%). Prevalence estimate differences were not associated with study or participant characteristics. In sum, GDS-15 ≥ 5 substantially overestimated depression prevalence. A cutoff of ≥ 8 was accurate overall, but heterogeneity was too high for implementation in practice. Validated diagnostic interviews should be used to estimate major depression prevalence among older adults.
      (© 2024. The Author(s).)
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    • Grant Information:
      PJT-156365 Canada CIHR; PJT-156365 Canada CIHR
    • Contributed Indexing:
      Investigator: A Krishnan; C He; TD Santo; D Neupane; NG Domínguez; E Brehaut; PM Bhandari; X Qiu; L Li; M Imran; EL Nassar; JPA Ioannidis; AK Allgaier; MHN Chagas; AT Isik; N Jetté; HH König; M Löbner; L Marsh; I Michopoulos; AA Mougias; CJ Nelson; A Pabst; TJ Quinn; SG Riedel-Heller; R Saracino; M Scherer; M Taylor-Rowan; M Volz; K Werheid; SB Weyerer
    • الموضوع:
      Date Created: 20240729 Date Completed: 20240729 Latest Revision: 20240806
    • الموضوع:
      20240807
    • الرقم المعرف:
      PMC11286862
    • الرقم المعرف:
      10.1038/s41598-024-68496-3
    • الرقم المعرف:
      39075146