Common viral infections inhibit egg laying in honey bee queens and are linked to premature supersedure.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Ovary*/virology ; Virus Diseases*/immunology; Animals ; Bees/virology ; Bees/physiology ; Bees/immunology ; Female ; Reproduction ; Oviposition ; Fertility

With their long lives and extreme reproductive output, social insect queens have escaped the classic trade-off between fecundity and lifespan, but evidence for a trade-off between fecundity and immunity has been inconclusive. This is in part because pathogenic effects are seldom decoupled from effects of immune induction. We conducted parallel, blind virus infection experiments in the laboratory and in the field to interrogate the idea of a reproductive immunity trade-off in honey bee (Apis mellifera) queens and to better understand how these ubiquitous stressors affect honey bee queen health. We found that queens injected with infectious virus had smaller ovaries and were less likely to recommence egg-laying than controls, while queens injected with UV-inactivated virus displayed an intermediate phenotype. In the field, heavily infected queens had smaller ovaries and infection was a meaningful predictor of whether supersedure cells were observed in the colony. Immune responses in queens receiving live virus were similar to queens receiving inactivated virus, and several of the same immune proteins were negatively associated with ovary mass in the field. This work supports the hypothesized relationship between virus infection and symptoms associated with queen failure and suggests that a reproductive-immunity trade-off is partially, but not wholly responsible for these effects.
(© 2024. The Author(s).)

Sci Rep. 2020 Nov 12;10(1):19610. (PMID: 33184302)
J Invertebr Pathol. 2009 Apr;101(1):77-9. (PMID: 19373971)
Arch Insect Biochem Physiol. 2008 Dec;69(4):155-67. (PMID: 18979500)
Insect Mol Biol. 2006 Oct;15(5):645-56. (PMID: 17069638)
PLoS One. 2016 Feb 10;11(2):e0147220. (PMID: 26863438)
Annu Rev Entomol. 2016;61:239-56. (PMID: 26667271)
J Insect Physiol. 2019 Jan;112:90-100. (PMID: 30578811)
R Soc Open Sci. 2020 Jul 8;7(7):200480. (PMID: 32874644)
Infect Genet Evol. 2020 Nov;85:104558. (PMID: 32947033)
Viruses. 2023 Jul 21;15(7):. (PMID: 37515283)
Insects. 2021 Jul 31;12(8):. (PMID: 34442255)
J Invertebr Pathol. 2008 Jun;98(2):184-9. (PMID: 18358488)
Mol Biol Evol. 2015 Dec;32(12):3173-85. (PMID: 26341296)
Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):962-7. (PMID: 16418279)
J Insect Physiol. 2016 Jun;89:1-8. (PMID: 26979384)
J Econ Entomol. 2019 Sep 23;112(5):2030-2039. (PMID: 31145456)
J Invertebr Pathol. 2020 Jan;169:107279. (PMID: 31738888)
J Invertebr Pathol. 2006 Jul;92(3):152-9. (PMID: 16793058)
Insects. 2013 Jan 04;4(1):90-103. (PMID: 26466797)
Viruses. 2020 May 14;12(5):. (PMID: 32422881)
BMC Vet Res. 2015 Mar 14;11:61. (PMID: 25889959)
Proc Biol Sci. 2016 Jun 29;283(1833):. (PMID: 27358367)
Age (Dordr). 2008 Sep;30(2-3):177-85. (PMID: 19424867)
Nucleic Acids Res. 2015 Apr 20;43(7):e47. (PMID: 25605792)
J Insect Sci. 2020 Jan 1;20(2):. (PMID: 32219449)
J Gen Virol. 2013 Mar;94(Pt 3):668-676. (PMID: 23223622)
J Invertebr Pathol. 2010 Jan;103 Suppl 1:S48-61. (PMID: 19909976)
Fish Shellfish Immunol. 2020 Dec;107(Pt B):480-489. (PMID: 32920203)
PLoS One. 2008;3(12):e4071. (PMID: 19115015)
J Invertebr Pathol. 2005 Oct;90(2):118-21. (PMID: 16214161)
J Virol. 2009 Nov;83(22):11560-8. (PMID: 19726502)
PLoS One. 2018 Sep 5;13(9):e0203444. (PMID: 30183759)
Int J Parasitol Parasites Wildl. 2022 May 10;18:157-171. (PMID: 35592272)
Viruses. 2023 May 22;15(5):. (PMID: 37243302)
Insects. 2017 May 08;8(2):. (PMID: 28481294)
FEBS Open Bio. 2022 Jan;12(1):51-70. (PMID: 34665931)
Viruses. 2020 Feb 22;12(2):. (PMID: 32098425)
Intervirology. 2018;61(1):36-41. (PMID: 30048981)
Front Microbiol. 2020 Apr 09;11:620. (PMID: 32328051)
Curr Opin Insect Sci. 2016 Aug;16:64-68. (PMID: 27720052)
Insects. 2019 Jan 08;10(1):. (PMID: 30626029)
Commun Biol. 2021 Jan 8;4(1):48. (PMID: 33420325)
Mol Ecol. 2016 May;25(9):1972-85. (PMID: 26880273)
Sci Rep. 2017 Jul 12;7(1):5242. (PMID: 28701778)
Sci Rep. 2016 Sep 09;6:33065. (PMID: 27608961)
Curr Opin Insect Sci. 2016 Aug;16:1-8. (PMID: 27720042)
J Biol Chem. 2000 Mar 17;275(11):7505-14. (PMID: 10713054)
Nat Methods. 2020 Jan;17(1):41-44. (PMID: 31768060)
Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7128-33. (PMID: 17438290)
Insect Biochem Mol Biol. 2011 Dec;41(12):968-81. (PMID: 22001069)
Viruses. 2019 Jan 29;11(2):. (PMID: 30699904)
PLoS One. 2011 Jan 25;6(1):e16217. (PMID: 21283547)
Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7317-7325. (PMID: 32188787)
J Proteome Res. 2022 Sep 2;21(9):2104-2113. (PMID: 35793413)
Proc Biol Sci. 2016 Jan 13;283(1822):. (PMID: 26763704)
Proc Biol Sci. 2024 Jan 31;291(2015):20232463. (PMID: 38264776)
Nutrients. 2015 Oct 22;7(10):8818-29. (PMID: 26506386)
Anal Chem. 2003 Feb 1;75(3):663-70. (PMID: 12585499)
J Invertebr Pathol. 2011 Mar;106(3):380-5. (PMID: 21156180)
J Insect Physiol. 2022 Jan;136:104347. (PMID: 34902433)
PLoS One. 2023 May 10;18(5):e0274065. (PMID: 37163509)
Sci Rep. 2022 Sep 23;12(1):15857. (PMID: 36151143)
Proc Biol Sci. 2017 Jul 12;284(1858):. (PMID: 28701554)

264PRO Genome Canada; 374PRO Genome BC

Date Created: 20240727 Date Completed: 20240728 Latest Revision: 20240806

20240806

PMC11283550

10.1038/s41598-024-66286-5

39068210