Deisolation in the Healthcare Setting Following Recent COVID-19 Infection.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI

COVID-19*/epidemiology ; COVID-19*/transmission ; COVID-19*/virology ; SARS-CoV-2*/isolation & purification ; SARS-CoV-2*/immunology ; Health Personnel*; Humans ; Patient Isolation

Background: Deisolation of persons infected with SARS-CoV-2, the virus that causes COVID-19, presented a substantial challenge for healthcare workers and policy makers, particularly during the early phases of the pandemic. Data to guide deisolation of SARS-CoV-2-infected patients remain limited, and the risk of transmitting and acquiring infection has changed with the evolution of SARS-CoV-2 variants and population immunity from previous vaccination or infection, or both.
Aims: This review examines the evidence to guide the deisolation of SARS-CoV-2-infected inpatients within the hospital setting when clinically improving and also of healthcare workers with COVID-19 prior to returning to work.
Methods: A review was performed using relevant search terms in Medline, EMBASE, Google Scholar, and PubMed.
Results and Discussion: The evidence is reviewed with regards to the nature of SARS-CoV-2 transmission, the role of testing to guide deisolation, and the impact of SARS-CoV-2-specific immunity. A paradigm and recommendations are proposed to guide deisolation for inpatients and return to work for healthcare workers.

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Keywords: COVID-19; SARS-CoV-2; deisolation; healthcare; healthcare worker; infection control

SARS-CoV-2 variants

Date Created: 20240727 Date Completed: 20240728 Latest Revision: 20240729

20240729

PMC11281359

10.3390/v16071131

39066294