Neurodevelopment Is Dependent on Maternal Diet: Placenta and Brain Glucose Transporters GLUT1 and GLUT3.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Glucose Transporter Type 3*/metabolism ; Glucose Transporter Type 3*/genetics ; Brain*/metabolism ; Placenta*/metabolism ; Glucose Transporter Type 1*/metabolism ; Neurodevelopmental Disorders*/etiology; Humans ; Pregnancy ; Female ; Animals ; Maternal Nutritional Physiological Phenomena ; Diet, Ketogenic ; Diet, High-Fat/adverse effects ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/metabolism ; Glucose/metabolism

Glucose is the primary energy source for most mammalian cells and its transport is affected by a family of facilitative glucose transporters (GLUTs) encoded by the SLC2 gene. GLUT1 and GLUT3, highly expressed isoforms in the blood-brain barrier and neuronal membranes, respectively, are associated with multiple neurodevelopmental disorders including epilepsy, dyslexia, ADHD, and autism spectrum disorder (ASD). Dietary therapies, such as the ketogenic diet, are widely accepted treatments for patients with the GLUT1 deficiency syndrome, while ameliorating certain symptoms associated with GLUT3 deficiency in animal models. A ketogenic diet, high-fat diet, and calorie/energy restriction during prenatal and postnatal stages can also alter the placental and brain GLUTs expression with long-term consequences on neurobehavior. This review focuses primarily on the role of diet/energy perturbations upon GLUT isoform-mediated emergence of neurodevelopmental and neurodegenerative disorders.

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HD-81206 National Institute of Health; NS123883 National Institute of Health

Keywords: Huntington’s disease; brain; glucose transporter; glucose transporter 3; maternal diet; neurodegenerative disorders; neurodevelopment; neurodevelopmental disorders; placenta; postnatal diet

0 (Glucose Transporter Type 3)
0 (Glucose Transporter Type 1)
0 (SLC2A3 protein, human)
0 (SLC2A1 protein, human)
IY9XDZ35W2 (Glucose)

Date Created: 20240727 Date Completed: 20240727 Latest Revision: 20240813

20240813

PMC11279700

10.3390/nu16142363

39064806