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The Safety Profile of Vitamin D Supplements Using Real-World Data from 445,493 Participants of the UK Biobank: Slightly Higher Hypercalcemia Prevalence but Neither Increased Risks of Kidney Stones nor Atherosclerosis.
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- معلومة اضافية
- المصدر:
Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
- بيانات النشر:
Original Publication: Basel, Switzerland : MDPI Publishing
- الموضوع:
- نبذة مختصرة :
Background : Potential calcium-related adverse events of vitamin D supplement use have not been addressed in large-scale, real-world data so far. Methods: Leveraging data from the UK Biobank, encompassing 445,493 individuals aged 40-69, we examined associations of high 25-hydroxyvitamin (25(OH)D) levels ≥ 100 nmol/L and vitamin D supplementation with hypercalcemia (serum calcium > 2.6 mmol/L), kidney stones, and atherosclerosis assessments (pulse wave arterial stiffness index and carotid intima-medial thickness). Regression models were comprehensively adjusted for 49 covariates. Results: Approximately 1.5% of the participants had high 25(OH)D levels, 4.3% regularly used vitamin D supplements, and 20.4% reported regular multivitamin use. At baseline, the hypercalcemia prevalence was 1.6%, and 1.1% was diagnosed with kidney stones during follow-up. High 25(OH)D levels were neither associated with calcium-related adverse events nor atherosclerosis assessments. Vitamin D and multivitamin supplementation were associated with an increased prevalence of hypercalcemia (odds ratios and 95% confidence intervals: 1.46 [1.32-1.62] and 1.11 [1.04-1.18], respectively) but were neither associated with atherosclerosis nor future kidney stones. Conclusions: High 25(OH)D levels observable in routine care were not associated with any adverse outcome. Vitamin D users have a slightly higher prevalence of hypercalcemia, possibly due to co-supplementation with calcium, but without a higher atherosclerosis prevalence or risk of kidney stones.
- References:
Nutrients. 2017 Mar 18;9(3):. (PMID: 28335477)
J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. (PMID: 21646368)
Cancers (Basel). 2011 Jan 06;3(1):213-26. (PMID: 24212614)
Int J Clin Pract. 2021 Jul;75(7):e14181. (PMID: 33759301)
Resuscitation. 2010 Oct;81(10):1400-33. (PMID: 20956045)
BMJ. 2009 Jun 29;338:b2393. (PMID: 19564179)
Am J Clin Nutr. 2016 Oct;104(4):1039-1051. (PMID: 27604776)
BMJ. 2014 Nov 18;349:g6330. (PMID: 25406188)
Can Fam Physician. 2010 Mar;56(3):244-6, e90-2. (PMID: 20228307)
PLoS Med. 2015 Mar 31;12(3):e1001779. (PMID: 25826379)
J Intern Med. 2023 Mar;293(3):384-397. (PMID: 36208176)
EFSA J. 2023 Aug 08;21(8):e08145. (PMID: 37560437)
BMJ. 2020 Feb 12;368:m131. (PMID: 32051121)
J Cardiol. 2013 Dec;62(6):361-5. (PMID: 23867332)
Nat Rev Cancer. 2014 May;14(5):342-57. (PMID: 24705652)
Kidney Int. 2012 May;81(10):937-939. (PMID: 22543902)
J Clin Invest. 2005 Oct;115(10):2598-608. (PMID: 16200192)
Eur Heart J. 2013 Jul;34(28):2159-219. (PMID: 23771844)
BMC Med Genomics. 2023 Apr 20;16(1):82. (PMID: 37081554)
J Natl Med Assoc. 2017 Spring;109(1):14-20. (PMID: 28259209)
Endocr Connect. 2015 Jun;4(2):128-35. (PMID: 25956908)
Clin J Am Soc Nephrol. 2008 Nov;3(6):1800-6. (PMID: 18922995)
J Am Soc Nephrol. 2004 Dec;15(12):3225-32. (PMID: 15579526)
J Clin Endocrinol Metab. 2022 Feb 17;107(3):e1159-e1166. (PMID: 34669929)
Horm Metab Res. 2020 May;52(5):305-315. (PMID: 32403145)
Am J Physiol. 1999 Aug;277(2):F157-75. (PMID: 10444570)
J Steroid Biochem Mol Biol. 2020 Apr;198:105561. (PMID: 31809869)
Arch Intern Med. 2004 Apr 26;164(8):885-91. (PMID: 15111375)
Int J Epidemiol. 2008 Apr;37(2):234-44. (PMID: 18381398)
J Int Soc Sports Nutr. 2015 Aug 19;12:33. (PMID: 26288575)
Clin Med (Lond). 2012 Oct;12(5):467-71. (PMID: 23101150)
Blood Press Monit. 2016 Feb;21(1):49-53. (PMID: 26461882)
Biomed Res Int. 2018 May 22;2018:9276380. (PMID: 29951549)
N Engl J Med. 1984 Jul 12;311(2):73-80. (PMID: 6330548)
Stat Med. 2010 Apr 30;29(9):1037-57. (PMID: 20087875)
Arch Biochem Biophys. 2000 Feb 15;374(2):334-8. (PMID: 10666315)
Urology. 2016 Jan;87:40-5. (PMID: 26494294)
Eur J Nutr. 2023 Jun;62(4):1833-1844. (PMID: 36853379)
J Am Coll Cardiol. 2011 Jul 5;58(2):186-92. (PMID: 21718915)
Int Urol Nephrol. 2016 Aug;48(8):1243-1246. (PMID: 27093967)
J Clin Med. 2015 Mar 09;4(3):414-24. (PMID: 26239247)
J Inflamm Res. 2014 May 29;7:69-87. (PMID: 24971027)
Annu Rev Physiol. 2022 Feb 10;84:559-583. (PMID: 34699268)
Dermatoendocrinol. 2017 Apr 13;9(1):e1300213. (PMID: 28458767)
Am J Clin Nutr. 2006 Jul;84(1):18-28. (PMID: 16825677)
Lancet Diabetes Endocrinol. 2014 Jan;2(1):76-89. (PMID: 24622671)
BMJ. 2015 Jun 02;350:h2723. (PMID: 26037642)
Atherosclerosis. 2015 Dec;243(2):486-92. (PMID: 26520904)
Eur Heart J. 2012 Nov;33(22):2873-81. (PMID: 22719023)
- Contributed Indexing:
Keywords: adverse events; atherosclerosis; hypercalcemia; kidney stone risk; real-world evidence; serum 25-hydroxyvitamin D levels; vitamin D supplementation
- الرقم المعرف:
1406-16-2 (Vitamin D)
A288AR3C9H (25-hydroxyvitamin D)
SY7Q814VUP (Calcium)
- الموضوع:
Date Created: 20240727 Date Completed: 20240727 Latest Revision: 20240729
- الموضوع:
20240729
- الرقم المعرف:
PMC11279740
- الرقم المعرف:
10.3390/nu16142251
- الرقم المعرف:
39064694
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