Vitamin D in Central Nervous System: Implications for Neurological Disorders.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Vitamin D*/metabolism ; Vitamin D*/therapeutic use ; Central Nervous System*/metabolism ; Central Nervous System*/drug effects ; Vitamin D Deficiency*/metabolism ; Vitamin D Deficiency*/drug therapy ; Nervous System Diseases*/metabolism ; Nervous System Diseases*/drug therapy; Humans ; Animals ; Dietary Supplements ; Receptors, Calcitriol/metabolism ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/drug therapy

Vitamin D, obtained from diet or synthesized internally as cholecalciferol and ergocalciferol, influences bodily functions through its most active metabolite and the vitamin D receptor. Recent research has uncovered multiple roles for vitamin D in the central nervous system, impacting neural development and maturation, regulating the dopaminergic system, and controlling the synthesis of neural growth factors. This review thoroughly examines these connections and investigates the consequences of vitamin D deficiency in neurological disorders, particularly neurodegenerative diseases. The potential benefits of vitamin D supplementation in alleviating symptoms of these diseases are evaluated alongside a discussion of the controversial findings from previous intervention studies. The importance of interpreting these results cautiously is emphasised. Furthermore, the article proposes that additional randomised and well-designed trials are essential for gaining a deeper understanding of the potential therapeutic advantages of vitamin D supplementation for neurological disorders. Ultimately, this review highlights the critical role of vitamin D in neurological well-being and highlights the need for further research to enhance our understanding of its function in the brain.

Iran J Pharm Res. 2016 Fall;15(4):941-950. (PMID: 28243293)
Neurosci Lett. 2003 Jun 5;343(2):139-43. (PMID: 12759183)
Cephalalgia. 2018 Jan;38(1):1-211. (PMID: 29368949)
Cochrane Database Syst Rev. 2015 May 06;(5):CD007771. (PMID: 25946084)
Sleep. 2015 Feb 01;38(2):251-7. (PMID: 25581929)
Neuroscience. 2016 May 13;322:28-38. (PMID: 26820600)
Nutrients. 2020 Dec 29;13(1):. (PMID: 33383952)
Nord J Psychiatry. 2018 Apr;72(3):221-225. (PMID: 29308715)
J Gerontol A Biol Sci Med Sci. 2012 Nov;67(11):1205-11. (PMID: 22503994)
Neurochem Res. 2006 Apr;31(4):533-9. (PMID: 16758362)
Schizophr Bull. 2010 Nov;36(6):1073-8. (PMID: 20833696)
Eur J Neurosci. 2000 Oct;12(10):3721-8. (PMID: 11029642)
Tohoku J Exp Med. 2007 Jul;212(3):275-82. (PMID: 17592215)
Osteoporos Int. 2009 Feb;20(2):231-7. (PMID: 18528724)
J Clin Sleep Med. 2012 Dec 15;8(6):693-7. (PMID: 23243403)
Psychiatry Investig. 2010 Dec;7(4):243-50. (PMID: 21253407)
J Clin Neurosci. 2013 Nov;20(11):1550-3. (PMID: 23815870)
Schizophr Res. 2004 Apr 1;67(2-3):237-45. (PMID: 14984883)
Biochem Biophys Res Commun. 2015 Apr 24;460(1):53-71. (PMID: 25998734)
Pediatrics. 2011 Sep;128(3):e488-95. (PMID: 21844053)
Nat Commun. 2015 Apr 09;6:6761. (PMID: 25854456)
Medicina (Kaunas). 2019 Jun 28;55(7):. (PMID: 31261815)
Curr Opin Neurobiol. 2009 Apr;19(2):220-30. (PMID: 19481443)
J Chem Neuroanat. 2005 Jan;29(1):21-30. (PMID: 15589699)
J Intern Med. 2015 Jan;277(1):45-57. (PMID: 24995480)
J Chin Med Assoc. 2016 Jan;79(1):34-8. (PMID: 26391786)
Nutr Neurosci. 2018 Sep;21(7):511-519. (PMID: 28475473)
J Child Adolesc Psychopharmacol. 2015 Jun;25(5):415-24. (PMID: 26091195)
J Affect Disord. 2020 May 15;269:28-35. (PMID: 32217340)
J Orthop Res. 2016 Nov;34(11):2031-2037. (PMID: 26932507)
J Child Neurol. 2015 Oct;30(11):1428-32. (PMID: 25637647)
Lancet Psychiatry. 2022 Apr;9(4):e13. (PMID: 35305747)
Medicina (Kaunas). 2019 Jul 05;55(7):. (PMID: 31284484)
Mol Aspects Med. 2008 Dec;29(6):407-14. (PMID: 18727936)
Biol Psychiatry. 1999 Nov 1;46(9):1219-33. (PMID: 10560027)
J Am Geriatr Soc. 2012 Dec;60(12):2197-205. (PMID: 23176129)
Eur J Neurol. 2018 Jan;25(1):59-70. (PMID: 28872215)
Clin J Pain. 2013 Apr;29(4):341-7. (PMID: 22699141)
Neuroreport. 2004 Mar 22;15(4):677-80. (PMID: 15094474)
BMC Psychiatry. 2012 Jun 26;12:68. (PMID: 22734499)
Med Hypotheses. 2016 Mar;88:74-8. (PMID: 26880644)
J Affect Disord. 2001 Sep;66(1):1-11. (PMID: 11532527)
Expert Rev Neurother. 2008 Jul;8(7):1101-13. (PMID: 18590480)
Psychiatry Clin Neurosci. 2017 Feb;71(2):77-103. (PMID: 27800654)
Exp Mol Pathol. 2015 Apr;98(2):240-5. (PMID: 25681066)
Psychiatry Res. 2018 Dec;270:104-110. (PMID: 30245372)
J Res Med Sci. 2013 Mar;18(Suppl 1):S66-70. (PMID: 23961291)
PLoS One. 2013;8(2):e30243. (PMID: 23405058)
Dialogues Clin Neurosci. 2008;10(3):279-89. (PMID: 18979941)
Mov Disord. 2007 Mar 15;22(4):461-8. (PMID: 17230473)
Neurodegener Dis. 2014;13(2-3):75-81. (PMID: 24192346)
J Clin Mov Disord. 2018 Oct 31;5:7. (PMID: 30397507)
Neurobiol Aging. 2014 May;35(5):1198-205. (PMID: 24378089)
FASEB J. 2018 Feb;32(2):819-828. (PMID: 29018141)
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4359-66. (PMID: 25267625)
Redox Biol. 2019 Sep;26:101295. (PMID: 31421410)
Life Sci. 2019 Jun 1;226:77-90. (PMID: 30980848)
Brain Behav. 2020 Nov;10(11):e01760. (PMID: 32945627)
Transl Psychiatry. 2018 Mar 13;8(1):61. (PMID: 29531242)
J Biol Chem. 2014 Apr 25;289(17):11681-11694. (PMID: 24619416)
Brain Behav. 2018 Feb 09;8(3):e00936. (PMID: 29541546)
Schizophr Bull. 2004;30(4):923-34. (PMID: 15954198)
Lancet. 2017 Nov 4;390(10107):2084-2098. (PMID: 28552366)
Tohoku J Exp Med. 2012;228(3):189-96. (PMID: 23076256)
J Parkinsons Dis. 2016;6(1):29-37. (PMID: 26756741)
Lancet. 2016 Apr 9;387(10027):1561-1572. (PMID: 26388529)
Vitam Horm. 2002;64:357-406. (PMID: 11898396)
Brain Inj. 2015 Sep;29(10):1165-1174. (PMID: 26083048)
J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):467-70. (PMID: 20214992)
Neurol Clin. 2019 Nov;37(4):651-671. (PMID: 31563225)
Mol Genet Genomic Med. 2016 Mar 04;4(3):322-43. (PMID: 27247960)
Atten Defic Hyperact Disord. 2014 Jun;6(2):73-8. (PMID: 24610453)
Vitam Horm. 2016;100:1-20. (PMID: 26827946)
Schizophr Res. 2016 Sep;176(1):52-71. (PMID: 26589391)
J Cell Biol. 2015 Dec 7;211(5):975-85. (PMID: 26644513)
Lancet. 2021 Apr 24;397(10284):1577-1590. (PMID: 33667416)
Nutr Neurosci. 2019 Nov;22(11):750-759. (PMID: 29447107)
J Child Adolesc Psychopharmacol. 2019 Nov;29(9):670-687. (PMID: 31368773)
Lancet Neurol. 2019 Apr;18(4):357-375. (PMID: 30773428)
Int J Mol Sci. 2017 Dec 19;18(12):. (PMID: 29257109)
Pediatr Int. 2014 Aug;56(4):515-9. (PMID: 24417979)
Neurosci Lett. 2010 Dec 17;486(3):220-3. (PMID: 20884326)
Immunol Res. 2017 Aug;65(4):913-919. (PMID: 28573424)
Nutr J. 2015 Aug 01;14:76. (PMID: 26231781)
Neurology. 2014 Sep 2;83(10):920-8. (PMID: 25098535)
Brain Res Dev Brain Res. 2004 Oct 15;153(1):61-8. (PMID: 15464218)
J Lipid Res. 2014 Jan;55(1):13-31. (PMID: 23564710)
CNS Drugs. 2019 Jul;33(7):619-637. (PMID: 31093951)
J Neuroimmunol. 2016 Mar 15;292:126-36. (PMID: 26943970)
Braz J Med Biol Res. 2014 Apr;47(4):349-54. (PMID: 24714817)
Sleep Med Rev. 2014 Aug;18(4):311-9. (PMID: 24075129)
Clin Interv Aging. 2016 May 04;11:513-22. (PMID: 27217733)
Nutrients. 2015 Sep 24;7(10):8251-60. (PMID: 26404359)
Mol Neurobiol. 2018 Mar;55(3):2443-2453. (PMID: 28365874)
Bipolar Disord. 2009 Dec;11(8):787-806. (PMID: 19922550)
Pain. 2007 Jul;130(1-2):166-76. (PMID: 17459586)
J Child Psychol Psychiatry. 2018 Jan;59(1):20-29. (PMID: 27868194)
Lancet. 2018 Aug 11;392(10146):508-520. (PMID: 30078460)
Front Neurol. 2016 Dec 08;7:218. (PMID: 28008324)
J Neurosci. 2001 Jan 1;21(1):98-108. (PMID: 11150325)
CNS Neurosci Ther. 2015 Aug;21(8):651-6. (PMID: 26096806)
eNeuro. 2020 May 22;7(3):. (PMID: 32393583)
J Alzheimers Dis. 2013;33(3):659-74. (PMID: 23042216)
BMC Psychiatry. 2014 May 08;14:134. (PMID: 24884774)
J Psychiatr Pract. 2014 Sep;20(5):329-37. (PMID: 25226193)
Front Psychiatry. 2019 Jan 25;10:13. (PMID: 30740064)
BMC Psychiatry. 2019 Feb 21;19(1):77. (PMID: 30791895)
Braz J Psychiatry. 2003 Oct;25(4):231-8. (PMID: 15328550)
Neuroreport. 2017 Jun 14;28(9):492-497. (PMID: 28430709)
Psychiatry Res. 2016 Sep 30;243:390-4. (PMID: 27449008)
J Biol Chem. 2003 Dec 5;278(49):49378-85. (PMID: 14507914)
Sci Rep. 2019 Oct 15;9(1):14792. (PMID: 31616023)
Horm Metab Res. 2015 Apr;47(4):239-46. (PMID: 25723858)
J Neurochem. 2023 Sep;166(5):779-789. (PMID: 37084159)
Eur J Pharmacol. 2007 Nov 14;573(1-3):111-5. (PMID: 17643415)
Proteomics. 2007 Mar;7(5):769-80. (PMID: 17295352)
Neuropathol Appl Neurobiol. 2013 Aug;39(5):458-84. (PMID: 23336971)
Mol Cell Endocrinol. 2017 Sep 15;453:131-143. (PMID: 28579120)
Physiol Genomics. 2016 Oct 1;48(10):719-738. (PMID: 27341833)
Neuroimage Clin. 2019;22:101728. (PMID: 30822718)
Pharmacol Rev. 2017 Apr;69(2):80-92. (PMID: 28202503)
Exp Ther Med. 2022 May;23(5):341. (PMID: 35401802)
Alzheimers Dement. 2014 May;10(3):296-302. (PMID: 23871764)
J Clin Psychopharmacol. 2016 Dec;36(6):588-592. (PMID: 27662458)
Neurosci Biobehav Rev. 2016 Jun;65:185-94. (PMID: 27073049)
J Psychiatr Res. 2017 Dec;95:48-53. (PMID: 28777983)
Nutr Neurosci. 2019 Sep;22(9):637-647. (PMID: 29338670)
BMJ. 2014 Dec 15;349:g7260. (PMID: 25516139)
Chest. 2014 Nov;146(5):1387-1394. (PMID: 25367475)
Mol Psychiatry. 2016 Aug;21(8):1009-26. (PMID: 27271499)
Food Sci Nutr. 2021 Jun 15;9(8):4169-4175. (PMID: 34401068)
Neuroscience. 2016 Oct 1;333:193-203. (PMID: 27450565)
Am J Clin Nutr. 2013 May;97(5):1004-13. (PMID: 23485413)
Curr Med Res Opin. 2019 Apr;35(4):715-723. (PMID: 30182753)
Physiol Behav. 2004 Jun;81(4):651-5. (PMID: 15178159)
FASEB J. 2015 Jun;29(6):2207-22. (PMID: 25713056)
Psychiatry Res. 2015 Sep 30;229(1-2):613-6. (PMID: 26027439)
Can J Physiol Pharmacol. 2015 May;93(5):311-8. (PMID: 25741777)
Brain Res. 1984 Apr 23;298(1):125-9. (PMID: 6547070)
Int J Mol Sci. 2022 Jan 27;23(3):. (PMID: 35163353)
Behav Brain Res. 2005 Feb 28;157(2):299-308. (PMID: 15639181)
J Prev Alzheimers Dis. 2018;5(3):175-183. (PMID: 29972210)
Nat Rev Dis Primers. 2018 May 03;4:18024. (PMID: 29722352)
Front Biosci (Landmark Ed). 2021 Jan 1;26(3):566-611. (PMID: 33049684)
J Nutr Health Aging. 2013 Mar;17(3):231-4. (PMID: 23459975)
Headache. 2018 Nov;58(10):1530-1540. (PMID: 30341768)
Eur J Clin Nutr. 2020 Jan;74(1):167-175. (PMID: 31197218)
PLoS Med. 2005 Oct;2(10):e263. (PMID: 16146415)
Neuroscience. 2003;118(3):641-53. (PMID: 12710973)
JAMA. 2020 Aug 4;324(5):471-480. (PMID: 32749491)
PLoS One. 2012;7(7):e40097. (PMID: 22808099)
PLoS One. 2008 Apr 09;3(4):e1944. (PMID: 18398470)
Sci Rep. 2018 Jun 27;8(1):9741. (PMID: 29950608)
J Headache Pain. 2010 Aug;11(4):301-7. (PMID: 20464624)
Int Clin Psychopharmacol. 2013 Sep;28(5):275-82. (PMID: 23694999)
Ann Hum Genet. 2011 Mar;75(2):201-10. (PMID: 21309754)
Pain Res Treat. 2015;2015:904967. (PMID: 26090221)
Epilepsy Behav. 2012 May;24(1):131-3. (PMID: 22503468)
Cureus. 2018 Jul 10;10(7):e2960. (PMID: 30214848)
PLoS One. 2011;6(12):e29354. (PMID: 22216257)
Int J Prev Med. 2019 Feb 12;10:17. (PMID: 30820304)
Psychiatry Res. 2018 Feb;260:360-365. (PMID: 29241119)
Ann N Y Acad Sci. 2010 Mar;1192:208-14. (PMID: 20392238)
J Pediatr Psychol. 2007 Jul;32(6):631-42. (PMID: 17556405)
BMJ Case Rep. 2016 Feb 02;2016:. (PMID: 26838301)
Biol Trace Elem Res. 2020 Aug;196(2):375-383. (PMID: 31691193)
Sleep Breath. 2019 Jun;23(2):595-601. (PMID: 30430372)
Nutrients. 2018 Jun 06;10(6):. (PMID: 29882776)
Aging Cell. 2022 Aug;21(8):e13670. (PMID: 35822270)
Biomedicines. 2022 Jul 28;10(8):. (PMID: 36009371)
Public Health Nutr. 2018 Aug;21(11):2022-2037. (PMID: 29559013)
Acta Paediatr. 2012 Jul;101(7):779-83. (PMID: 22372707)

110119FD4520 Nazarbayev University

Keywords: brain; calcitriol; neurological disorders; vitamin D

1406-16-2 (Vitamin D)
0 (Receptors, Calcitriol)

Date Created: 20240727 Date Completed: 20240727 Latest Revision: 20240729

20250114

PMC11277055

10.3390/ijms25147809

39063051